Drug therapy for the patient with resistant hypertension

Future Cardiology
Luca DonazzanFelix Mahfoud

Abstract

Resistant hypertension is associated with high morbidity and mortality. Resistant hypertension is defined as blood pressure above targets despite treatment with at least three antihypertensive drugs in adequate dose and combination. Nonadherence is a frequent cause of uncontrolled hypertension and can be improved by providing fixed dose (of two or three agents) single pill combination. Triple combination of the most widely used antihypertensive agents (renin-angiotensin-aldosterone system antagonists, calcium channel blockers and diuretics) is a safe and effective therapy. Fourth line therapy is the use of an aldosterone antagonist. Renal denervation and baroreceptor stimulation can be considered in patients who remained uncontrolled despite optimal medical therapy.

References

May 6, 1988·JAMA : the Journal of the American Medical Association·M H WeinbergerN S Fineberg
Aug 15, 1994·Annals of Internal Medicine·A G JohnsonR O Day
Apr 12, 2000·Coronary Artery Disease·P F Kokkinos, V Papademetriou
Dec 19, 2001·Annals of Internal Medicine·W M VollmerUNKNOWN DASH-Sodium Trial Collaborative Research Group
Apr 26, 2003·Journal of Hypertension·Eoin O'BrienUNKNOWN European Society of Hypertension Working Group on Blood Pressure Monitoring
Oct 24, 2003·American Journal of Hypertension·Mari Konishi NishizakaDavid A Calhoun
Mar 19, 2005·Journal of Hypertension·Rachel P WildmanJiang He
Apr 6, 2006·Annals of Internal Medicine·Patricia J ElmerUNKNOWN PREMIER Collaborative Research Group
Jan 31, 2007·Hypertension·William B White
Feb 21, 2007·Hypertension·Neil ChapmanUNKNOWN Anglo-Scandinavian Cardiac Outcomes Trial Investigators
Jul 27, 2007·Nature Clinical Practice. Cardiovascular Medicine·Chiew Wong, Thomas H Marwick
Aug 7, 2007·The American Journal of Medicine·Sripal BangaloreFranz H Messerli
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Margaret J Morris
Apr 2, 2008·The New England Journal of Medicine·UNKNOWN ONTARGET InvestigatorsCraig Anderson
Aug 13, 2008·Current Opinion in Nephrology and Hypertension·Pantelis A Sarafidis
Dec 5, 2008·The New England Journal of Medicine·Kenneth JamersonUNKNOWN ACCOMPLISH Trial Investigators
Feb 18, 2009·International Journal of Clinical Practice·M BurnierZ M Khan
Apr 6, 2011·Circulation·Ian M KronishDevin M Mann
Apr 23, 2011·Journal of the American College of Cardiology·John D BisognanoUNKNOWN DEBuT-HT and Rheos Feasibility Trial Investigators

❮ Previous
Next ❯

Citations

Mar 9, 2019·Current Pharmaceutical Design·Konstantinos P ImprialosCharles Faselis

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
sedation

Software Mentioned

ASPIRANT

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.