Drug therapy in spinal tuberculosis.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
S Rajasekaran, Gaurav Khandelwal

Abstract

Although the discovery of effective anti-tuberculosis drugs has made uncomplicated spinal tuberculosis a medical disease, the advent of multi-drug-resistant Mycobacterium tuberculosis and the co-infection of HIV with tuberculosis have led to a resurgence of the disease recently. The principles of drug treatment of spinal tuberculosis are derived from our experience in treating pulmonary tuberculosis. Spinal tuberculosis is classified to be a severe form of extrapulmonary tuberculosis and hence is included in Category I of the WHO classification. The tuberculosis bacilli isolated from patients are of four different types with different growth kinetics and metabolic characteristics. Hence multiple drugs, which act on the different groups of the mycobacteria, are included in each anti-tuberculosis drug regimen. Prolonged and uninterrupted chemotherapy (which may be 'short course' and 'intermittent' but preferably 'directly observed') is effective in controlling the infection. Spinal Multi-drug-resistant TB and spinal TB in HIV-positive patients present unique problems in management and have much poorer prognosis. Failure of chemotherapy and emergence of drug resistance are frequent due to the failure of compliance hence all effort...Continue Reading

References

Jun 1, 1991·Journal of Neuroscience Methods·F ViennotG Gombos
Apr 28, 1994·The New England Journal of Medicine·S E WeisB H Foresman
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·R D MooreR E Chaisson
Apr 8, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W J BurmanC Peloquin
May 17, 2000·The Journal of Bone and Joint Surgery. British Volume·R Lemaire, J B Masson
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·W J Burman, B E Jones
Feb 14, 2004·Lancet·Joia S MukherjeeKwonjune J Seung
Jun 9, 2005·JAMA : the Journal of the American Medical Association·Christopher DyeMario C Raviglione
Sep 5, 2006·Respiratory Medicine·Thomas M Daniel
Aug 11, 2011·The European Respiratory Journal·D FalzonM Zignol

❮ Previous
Next ❯

Citations

Aug 27, 2015·The Journal of the American Academy of Orthopaedic Surgeons·Michael R MurrayWellington K Hsu
Mar 13, 2014·Orthopaedics & Traumatology, Surgery & Research : OTSR·S VaratharajahJ-P Steib
Feb 3, 2009·Current Topics in Developmental Biology·Irene E Zohn, Anjali A Sarkar
Aug 26, 2016·Asian Spine Journal·Pankaj KandwalArvind Jayaswal
Oct 30, 2015·Der Unfallchirurg·S RajasekaranA P Shetty
Jan 5, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Robert C Mulholland
Sep 23, 2014·JBJS Reviews·S RajasekaranAjoy Prasad Shetty
Jan 11, 2020·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Kaustubh AhujaPankaj Kandwal
Jul 3, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Wenjing WangYing Zhan
Oct 23, 2018·BioMed Research International·Guangru CaoPeng Wang
Oct 4, 2018·Current Reviews in Musculoskeletal Medicine·Barrett S BoodyAlexander R Vaccaro
Dec 24, 2018·Global Spine Journal·S RajasekaranRishi Mugesh Kanna
Nov 25, 2017·Journal of Affective Disorders·Kelly Rootes-MurdyPeter P Zandi
Aug 4, 2021·Global Spine Journal·Sunil BhosaleNandan Marathe
Nov 12, 2021·Expert Opinion on Drug Delivery·Long HuaYihe Hu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Related Papers

Orthopaedics & Traumatology, Surgery & Research : OTSR
V P DjientcheuM A Sosso
European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Carlos Pigrau-Serrallach, Dolores Rodríguez-Pardo
European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Kin Cheung Mak, Kenneth M C Cheung
European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Guohua LüIvan Cheng
© 2021 Meta ULC. All rights reserved