Drug Weaponry to Fight Against SARS-CoV-2

Frontiers in Molecular Biosciences
Elena Cabezón, Ignacio Arechaga

Abstract

The current outbreak of SARS-CoV-2 virus has caused a large increase in mortality and morbidity associated with respiratory diseases. Huge efforts are currently ongoing to develop a vaccine against this virus. However, alternative approaches could be considered in the fight against this disease. Among other strategies, structural-based drug design could be an effective approach to generate specific molecules against SARS-CoV-2, thus reducing viral burden in infected patients. Here, in addition to this structural approach, we also revise several therapeutic strategies to fight against this viral threat. Furthermore, we report ACE-2 genetic polymorphic variants affecting residues involved in close contacts with SARS-CoV-2 that might be associated to different infection risks. These analyses could provide valuable information to predict the course of the disease.

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Citations

May 31, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yusuf Oloruntoyin AyipoMohd Nizam Mordi

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Methods Mentioned

BETA
glycosylation
phage display

Software Mentioned

UCSF Chimera
Ensembl

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