Drugs for neuroprotection after birth asphyxia: Pharmacologic adjuncts to hypothermia

Seminars in Perinatology
Frank van Bel, Floris Groenendaal

Abstract

An adverse outcome is still encountered in 45% of full-term neonates with perinatal asphyxia who are treated with moderate hypothermia. At present pharmacologic therapies are developed to be added to hypothermia. In the present article, these potential neuroprotective interventions are described based on the molecular pathways set in motion during fetal hypoxia and following reoxygenation and reperfusion after birth. These pathways include excessive production of excitotoxins with subsequent over-stimulation of NMDA receptors and calcium influx in neuronal cells, excessive production of reactive oxygen and nitrogen species, activation of inflammation leading to inappropriate apoptosis, and loss of neurotrophic factors. Possibilities for pharmacologic combination therapy, where each drug will be administered based on the optimal point of time in the cascade of destructive molecular reactions, may further reduce brain damage due to perinatal asphyxia.

References

Mar 9, 1987·FEBS Letters·P C MoorhouseJ M Gutteridge
Nov 15, 1995·JAMA : the Journal of the American Medical Association·J M ReinischD B Rubin
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Nov 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·M LeveneR Hartley
Dec 16, 1998·International Journal of Molecular Medicine·W M CampanaJ S O'Brien
Sep 9, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·G JahnkeC Price
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Cacha Peeters-ScholteFloris Groenendaal
Feb 15, 2003·Brain Research. Developmental Brain Research·Arjan ScheepensCarlos E Blanco
Mar 26, 2003·Free Radical Biology & Medicine·Frank PlaisantPierre Gressens
Nov 5, 2004·The New England Journal of Medicine·Donna M Ferriero
Dec 31, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maj HedtjärnHenrik Hagberg
Mar 26, 2005·Current Opinion in Neurology·Marianne Thoresen, Andrew Whitelaw
Jul 5, 2005·Trends in Pharmacological Sciences·Jean A BoutinPhilippe Delagrange
Sep 6, 2005·Brain Research·Susanne SchubertReinhard Bauer
Sep 16, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·De-Xiang XuWei Wei
Apr 18, 2006·Lancet·L PostonUNKNOWN Vitamins in Pre-eclampsia (VIP) Trial Consortium
Jun 1, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cora H A NijboerCobi J Heijnen
Dec 13, 2006·Pediatric Neurology·Tamer GunesIsin Gunes
Sep 1, 2007·Developmental Neuroscience·Cora H A NijboerFloris Groenendaal
Mar 7, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·B O ShoumanH Aly
Apr 19, 2008·Stroke; a Journal of Cerebral Circulation·Cora H NijboerAnnemieke Kavelaars
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anna-Leena SirénHannelore Ehrenreich
Jan 15, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marianne ThoresenJohn Dingley
Feb 24, 2009·Annals of Neurology·Haitao JiRichard B Silverman
Apr 17, 2009·Journal of Neuroinflammation·Christopher C Leonardo, Keith R Pennypacker

❮ Previous
Next ❯

Citations

Jun 22, 2018·The Journal of Physiology·Stacey J ElleryDavid W Walker
Jul 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Helena ParfenovaCharles W Leffler
Aug 9, 2017·Developmental Medicine and Child Neurology·Nienke WagenaarFrank van Bel
May 26, 2017·Developmental Medicine and Child Neurology·Nathalie H P ClaessensManon J N L Benders
Jun 3, 2021·International Journal of Molecular Sciences·Filipe Gonçalves CostaFrank Van Bel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Xiyong Fan, Frank van Bel
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
E SalibaJ Laugier
© 2022 Meta ULC. All rights reserved