Drugs for preventing tuberculosis in people at risk of multiple-drug-resistant pulmonary tuberculosis.

The Cochrane Database of Systematic Reviews
A FraserL Leibovici

Abstract

The emergence and spread of multiple-drug-resistant tuberculosis (MDR-TB), caused by strains of Mycobacterium tuberculosis resistant to at least isoniazid and rifampicin, is a potential threat to global tuberculosis control. Treatment is prolonged, expensive, more toxic than treatment of susceptible tuberculosis, and often unsuccessful. Experts are still undecided on the management of people exposed to MDR-TB. To evaluate antituberculous drugs given to people exposed to MDR-TB in preventing active tuberculosis. We searched the Cochrane Infectious Diseases Group Specialized Register (January 2006), CENTRAL (The Cochrane Library 2006, Issue 1), MEDLINE (1966 to January 2006); EMBASE (1974 to January 2006), LILACS (1982 to January 2006), conference proceedings, and reference lists. We also contacted researchers and organizations. Randomized controlled trials comparing antituberculous drug regimens with an alternative antituberculous drug regimen, placebo, or no intervention given to people exposed to MDR-TB for preventing active tuberculosis. Two authors independently inspected titles and abstracts identified by the search in order to identify potentially relevant publications for inclusion and analysis. No randomized controlled t...Continue Reading

References

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Citations

Apr 28, 2009·Infectious Disease Clinics of North America·Leonard Leibovici, Matthew E Falagas
Jan 10, 2009·AORN Journal·Janice A Neil
Apr 17, 2016·MMW Fortschritte der Medizin·Adrian Gillissen
Apr 15, 2017·Microbiology Spectrum·Connie A Haley
Oct 13, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M J Mellado PeñaUNKNOWN Grupo de Trabajo de Tuberculosis de la Sociedad Española de Infectología Pediátrica

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