Drusen and lipid-filled retinal pigment epithelium cells in a rhesus macula

Veterinary Ophthalmology
Mark AndersonChristine A Curcio

Abstract

A middle-aged rhesus monkey with detailed clinical history exhibited progression of a macular abnormality with a variety of clinical drusen and pigment changes typical of the Cayo Santiago phenotype. Numerous frozen sections of one sample of the macular retina/retinal pigment epithelium (RPE)/choroid showed a single classical druse but extensive single and clustered lipid-filled RPE cells. The monkey exhibited functional outer retinal decline and an insignificant number of 'window defects' as found among signs of relatively benign human macular aging. The clinical and histologically defined results agree if lipid-filled RPE cells are included among the clinically apparent signs of drusen.

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Citations

May 11, 2011·Analytical and Bioanalytical Chemistry·Timothy J GarrettRichard A Yost
Aug 19, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter GourasMartha Neuringer
Oct 7, 2010·Retina·Richard F Spaide, Christine A Curcio
Oct 3, 2009·Journal of Lipid Research·Christine A CurcioMartin Rudolf
May 6, 2015·American Journal of Primatology·Irina V ZhdanovaLindsay A Farrer
Jun 19, 2012·Molecular Aspects of Medicine·Mark E PennesiRobert J Courtney
Sep 26, 2007·Vision Research·William W DawsonJanis Gonzalez-Martinez
Nov 5, 2017·Scientific Reports·Glenn YiuSara M Thomasy
Oct 26, 2018·Investigative Ophthalmology & Visual Science·Christine A Curcio
Feb 2, 2019·Investigative Ophthalmology & Visual Science·Martin RudolfMahdy Ranjbar
Oct 26, 2018·Investigative Ophthalmology & Visual Science·Christine A Curcio
Sep 11, 2021·Experimental Eye Research·Kira H LinAla Moshiri
Aug 25, 2009·Progress in Retinal and Eye Research·Christine A CurcioMartin Rudolf

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