Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration.

Ophthalmology
Aziz A KhanifarCynthia A Toth

Abstract

To categorize drusen ultrastructure in age-related macular degeneration (AMD) using spectral domain optical coherence tomography (SDOCT) and correlate the tomographic and photographic drusen appearances. Prospective case series. Thirty-one eyes of 31 patients with non-neovascular AMD. Subjects with drusen and a clinical diagnosis of AMD were enrolled in an SDOCT imaging study from August of 2005 to May of 2007. Foveal linear scans were acquired, and the image data were processed for analysis. Drusen were scored by 4 morphologic categories: shape, predominant internal reflectivity, homogeneity, and presence of overlying hyper-reflective foci. The prevalences of each morphologic pattern and combinations of morphologic patterns observed were calculated. The photographic appearance of each druse was compared with the tomographic classification. Interobserver and intraobserver agreement analysis was performed. Prevalence of morphologic parameters using SDOCT. Twenty-one eyes of 21 patients had SDOCT B-scans of adequate quality for analysis. On the basis of the above morphologic categories, 17 different drusen patterns were found in 120 total drusen. The most common was convex, homogeneous, with medium internal reflectivity, and with...Continue Reading

References

Feb 1, 1995·Ophthalmology·C A PuliafitoJ G Fujimoto
Sep 5, 2002·American Journal of Ophthalmology·Don H AndersonLincoln V Johnson
Sep 25, 2002·Circulation·Hiroshi YabushitaGuillermo J Tearney
Jan 21, 2006·The British Journal of Ophthalmology·C G PieroniJ S Duker
Mar 23, 2006·Physics in Medicine and Biology·Ying YangRuikang K Wang
Sep 5, 2006·Ophthalmology·Carol L ShieldsJerry A Shields
Feb 13, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·P ThévenazM Unser

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Citations

Feb 20, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ninita H BrownCynthia A Toth
Jan 25, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Gennady LandaPatricia M T Garcia
Oct 7, 2010·Retina·Richard F Spaide, Christine A Curcio
Sep 6, 2011·The British Journal of Ophthalmology·Christine A CurcioJiahn-Dar Huang
Jun 7, 2013·The British Journal of Ophthalmology·D Jackson ColemanR V Paul Chan
Oct 18, 2012·Investigative Ophthalmology & Visual Science·Jennifer H ActonVivienne C Greenstein
Mar 9, 2013·Investigative Ophthalmology & Visual Science·Zohar YehoshuaPhilip J Rosenfeld
Apr 27, 2013·Investigative Ophthalmology & Visual Science·Ronald P DanisUNKNOWN AREDS2 Study Group
Dec 3, 2013·Progress in Retinal and Eye Research·Nicole T M SaksensCarel B Hoyng
Jul 12, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Megan E LandMurray Brilliant
Aug 21, 2014·British Medical Bulletin·Tomas IlginisPraveen J Patel
Aug 29, 2012·Ophthalmic Research·Zohar Yehoshua, Philip J Rosenfeld
Apr 22, 2015·Journal of Clinical Medicine·Venkata Ramana Murthy ChavaliDwight Stambolian
Sep 3, 2013·Ophthalmology·Sina FarsiuUNKNOWN Age-Related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study Group
Aug 18, 2012·Survey of Ophthalmology·Pearse A KeaneAdnan Tufail
May 12, 2012·Molecular Aspects of Medicine·Priyatham S MettuScott W Cousins
Apr 24, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Arno P GöbelSteffen Schmitz-Valckenberg
Aug 25, 2009·Progress in Retinal and Eye Research·Christine A CurcioMartin Rudolf
Dec 2, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Zohar YehoshuaFernando Penha
Dec 2, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Pooja GodaraJoseph Carroll
Mar 10, 2016·Ophthalmology·Karen B SchaalWilliam J Feuer
Jan 25, 2012·Acta Ophthalmologica·Raimondo ForteEric H Souied
May 20, 2015·American Journal of Ophthalmology·Ferdinand G SchlanitzUrsula Schmidt-Erfurth
Jan 15, 2015·The British Journal of Ophthalmology·Naima Ben MoussaGiuseppe Querques
Sep 14, 2013·Progress in Retinal and Eye Research·Camiel J F BoonB Jeroen Klevering
Jul 25, 2013·Medical Image Analysis·Qiang ChenDaniel L Rubin
Nov 12, 2013·Progress in Retinal and Eye Research·Yogesan KanagasingamTien Y Wong
May 26, 2012·American Journal of Ophthalmology·Johannes P H van de VenThomas Theelen
Apr 1, 2011·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Pearse A Keane, Srinivas R Sadda

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