Abstract
To compare drusenoid maculopathy in monkeys with human age-related macular degeneration, and evaluate the influence of age, gender and caloric restriction. Examination by indirect ophthalmoscopy, slit-lamp biomicroscopy and fundus photography, including in some cases fluorescein angiography, was performed on 61 male and 60 female rhesus macaques of ages 10-39 years. Fifty-four of the monkeys were maintained on a calorically restricted diet (approximately 30% lower than control levels) and 67 on an approximately ad libitum diet for 2-19 years, with all other environmental factors held constant. Maculopathies were graded on a 5-point scale and the effects of age, sex, and diet on prevalence and severity were examined. The retinas of six monkeys with macular drusen, 19-28 years old, were examined histologically. Rhesus monkeys showed a high prevalence (61%) of drusenoid maculopathy. The prevalence and severity of the maculopathy increased with age (p = 0.012). Fully half of all monkeys aged 10-12 years had some detectable degree of drusen. This high prevalence in young adulthood indicates that drusen develop much earlier in rhesus monkeys than in humans, who develop early maculopathy most rapidly at 50-60 years of age, even when c...Continue Reading
References
Oct 1, 1978·Experimental Eye Research·A El-MoftyE A Balazs
Jan 1, 1992·The British Journal of Ophthalmology·G M HopeM B Sherwood
Jan 1, 1990·Eye·M C KillingsworthS H Sarks
Sep 1, 1990·Journal of Gerontology·D K IngramB M Marriott
Jul 1, 1990·Optometry and Vision Science : Official Publication of the American Academy of Optometry·W A Monaco, C M Wormington
Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P L PenfoldS H Sarks
Feb 1, 1986·Investigative Ophthalmology & Visual Science·T IshibashiS J Ryan
Jan 1, 1987·Retina·R J UlshaferM J Kessler
Jun 1, 1987·Mechanisms of Ageing and Development·M L KatzW G Robison
Apr 1, 1972·Journal of Comparative Pathology·K C BarnettP H Hague
Aug 1, 1974·American Journal of Ophthalmology·S J VainisiD J Apple
May 1, 1980·Australian Journal of Ophthalmology·S H Sarks
May 1, 1984·Ophthalmology·T J StaffordB S Fine
Apr 1, 1981·Archives of Ophthalmology·L Feeney-BurnsM Neuringer
Aug 1, 1980·Experimental Eye Research·A A El-MoftyP Gouras
Jun 1, 1994·Archives of Ophthalmology·K Dastgheib, W R Green
Feb 1, 1995·Ophthalmology·J R VingerlingP T de Jong
Oct 6, 2001·Progress in Retinal and Eye Research·G S HagemanR F Mullins
Sep 9, 2004·Science·George S RothDonald K Ingram
Jan 27, 2005·Investigative Ophthalmology & Visual Science·Shinsuke UmedaTakeshi Iwata
May 17, 2005·Mechanisms of Ageing and Development·David A Sinclair
Aug 16, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shinsuke UmedaTakeshi Iwata
Apr 26, 2006·Veterinary Ophthalmology·Mark AndersonChristine A Curcio
Oct 26, 2006·Interdisciplinary Topics in Gerontology·Julie A MattisonDonald K Ingram
Aug 13, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter GourasMartha Neuringer
Citations
Aug 13, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter GourasMartha Neuringer
May 8, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P GourasJ A Mattison
Mar 3, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter GourasJulie A Mattison
Oct 21, 2010·Expert Reviews in Molecular Medicine·Sam Khandhadia, Andrew Lotery
Nov 14, 2015·The Journal of Pathology·Shemin ZengRobert F Mullins
Jun 19, 2012·Molecular Aspects of Medicine·Mark E PennesiRobert J Courtney
Apr 3, 2012·Experimental Eye Research·Lisa PahlManfred Stuhrmann
Jun 19, 2012·Veterinary Ophthalmology·Andrea SteinmetzGerhard Oechtering
Oct 1, 2013·Experimental Eye Research·Lisa PahlManfred Stuhrmann
Sep 4, 2014·PloS One·Xiaoxia YangJeffrey W Fisher
Oct 25, 2016·PloS One·Koji M NishiguchiToru Nakazawa
Apr 12, 2018·Current Eye Research·P GourasL Ivert
Nov 5, 2017·Scientific Reports·Glenn YiuSara M Thomasy
Jul 1, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Erica L FletcherKirstan A Vessey
Feb 23, 2020·Investigative Ophthalmology & Visual Science·Glenn YiuSara M Thomasy
Apr 11, 2018·Acta Ophthalmologica·Niko Kivinen
Nov 6, 2015·Journal of Toxicologic Pathology·Kazumoto ShibuyaSeiji Otake
Sep 24, 2020·Nutrients·Sarah G FranciscoSheldon Rowan
Feb 2, 2019·Investigative Ophthalmology & Visual Science·Martin RudolfMahdy Ranjbar
Jul 14, 2021·Life Sciences·Baozhu ZengBing Huang