Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging

Investigative Ophthalmology & Visual Science
Catherine Bowes RickmanMikael Klingeborn

Abstract

Age-related macular degeneration is the leading cause of irreversible visual dysfunction in individuals over 65 in Western Society. Patients with AMD are classified as having early stage disease (early AMD), in which visual function is affected, or late AMD (generally characterized as either "wet" neovascular AMD, "dry" atrophic AMD or both), in which central vision is severely compromised or lost. Until recently, there have been no therapies available to treat the disorder(s). Now, the most common wet form of late-stage AMD, choroidal neovascularization, generally responds to treatment with anti-vascular endothelial growth factor therapies. Nevertheless, there are no current therapies to restore lost vision in eyes with advanced atrophic AMD. Oral supplementation with the Age-Related Eye Disease Study (AREDS) or AREDS2 formulation (antioxidant vitamins C and E, lutein, zeaxanthin, and zinc) has been shown to reduce the risk of progression to advanced AMD, although the impact was in neovascular rather than atrophic AMD. Recent findings, however, have demonstrated several features of early AMD that are likely to be druggable targets for treatment. Studies have established that much of the genetic risk for AMD is associated with ...Continue Reading

Citations

Jul 11, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Changshin YoonYeong Seok Kim
Feb 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Pravin U Dugel, Cheryl N Zimmer
Aug 12, 2015·The Journal of Cell Biology·Mei JiangDavid S Williams
Mar 2, 2016·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yaron A GreenZeev Dvashi
Apr 30, 2015·Experimental Eye Research·Jaimie Hoh KamGlen Jeffery
Jul 28, 2015·Experimental Eye Research·Keiichi ShibagakiMasatsugu Nakamura
Dec 2, 2014·Expert Opinion on Therapeutic Targets·Patrick L McGeer, Edith G McGeer
Jul 15, 2015·Analytical Cellular Pathology (Amsterdam)·Kenneth Maiese
Jun 13, 2015·Oxidative Medicine and Cellular Longevity·Kenneth Maiese
Dec 21, 2014·American Journal of Ophthalmology·Glenn YiuCynthia A Toth
Mar 5, 2015·Apoptosis : an International Journal on Programmed Cell Death·Hui ShiStephen E Moss
Nov 8, 2014·Molecular Biology of the Cell·Kimberly A ToopsAparna Lakkaraju
Jul 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Li Xuan TanAparna Lakkaraju
Jul 30, 2014·Stem Cells Translational Medicine·Roxanne H CrozeDennis O Clegg
Sep 24, 2016·IEEE Transactions on Medical Imaging·Leyuan FangSina Farsiu
May 10, 2017·Human Molecular Genetics·Robert F MullinsAndrew J Lotery
Jun 28, 2018·Journal of Lipid Research·Norimitsu BanRajendra S Apte
Dec 15, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·David F WoodwardNeil J Poloso
Jul 11, 2019·Current Molecular Medicine·Liu YangMing Jin
Nov 23, 2019·International Journal of Molecular Sciences·Juha M T HyttinenKai Kaarniranta
Feb 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eun-Jeong ChoiHea-Young Cho
Feb 23, 2020·Investigative Ophthalmology & Visual Science·Glenn YiuSara M Thomasy
Mar 3, 2020·Expert Opinion on Therapeutic Targets·Saeed MehrzadiAzam Hosseinzadeh
Mar 7, 2020·Journal of Pineal Research·Hernán H DiéguezDamián Dorfman
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Audrey VoisinNicolas Leveziel
Aug 2, 2020·The Journal of Biological Chemistry·Una L KellyCatherine Bowes Rickman
Apr 4, 2017·Oxidative Medicine and Cellular Longevity·Koji OhashiMasatsugu Nakamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

© 2021 Meta ULC. All rights reserved