Dry Eye Disease Is Already Present in Hematological Patients Before Hematopoietic Stem Cell Transplantation

Cornea
Giuseppe GiannaccarePiera Versura

Abstract

To analyze ocular surface parameters in patients before hematopoietic stem cell transplantation (HSCT) and to correlate them with hematological characteristics. This is a retrospective analysis of prospectively collected data from 203 patients undergoing HSCT. Demographic data and hematological parameters (disorder type and stage) were collected from clinical charts. Ocular surface parameters (ocular surface disease index; Schirmer test I; tear film break-up time; corneal esthesiometry; and corneal and conjunctival staining) were analyzed the day before beginning the conditioning treatment for HSCT preparation. A high prevalence of dry eye (DE) was found: 116 patients (57.2%) were diagnosed as not suffering from DE, whereas 87 patients (42.8%) were diagnosed as having DE. Of these, 26 were classified as dry eye workshot (DEWS) severity score 1, 46 as DEWS score 2, and 15 as DEWS score 3. Tear film break-up time was found to be the only parameter statistically worse in the chronic lymphoproliferative disorder group compared with the stem cell malignancy group. Older age [odds ratio (OR) 1.03], female sex (OR 2.03), advanced stage of hematological disease (OR 1.4), and previous auto- or allo-HSCT (OR 1.9) showed a significant pos...Continue Reading

References

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Citations

Jan 10, 2018·Annals of Clinical Biochemistry·Piera VersuraEmilio C Campos
Dec 21, 2019·Translational Vision Science & Technology·Marc PellegriniGiusepp Giannaccare
Feb 29, 2020·Ophthalmology and Therapy·Giuseppe GiannaccareVincenzo Scorcia
Sep 14, 2019·Journal of Clinical Medicine·Mostafa HeidariAlireza Mashaghi
Jan 29, 2021·Journal of Cellular Physiology·Alice BruscoliniAlessandro Lambiase
Mar 10, 2021·Bone Marrow Transplantation·Alexandra A PietraszkiewiczRachel J Bishop
Apr 4, 2021·International Journal of Molecular Sciences·Eugene Appenteng Osae, Philipp Steven

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