Dry film refractive index as an important parameter for ultra-low fouling surface coatings

Biomacromolecules
Norman D BraultShaoyi Jiang

Abstract

Here we demonstrate that the film refractive index (RI) can be an even more important parameter than film thickness for identifying nonfouling polymer films to undiluted human blood plasma and serum. The film thickness and RI are two parameters obtained from ellipsometry. Previously, film thickness has been correlated to ultra-low fouling properties. Practically, the film RI can be used to characterize polymer density but is often overlooked. By varying the water content in the surface-initiated atom transfer radical polymerization of zwitterionic carboxybetaine, a minimum of ∼1.5 RI units was necessary to achieve <5 ng/cm(2) of adsorption from undiluted human serum. A model of the film structure versus water content was also developed. These results point to an important parameter and simple approach for identifying surface coatings suitable for real-world applications involving complex media. Therefore, ultra-low fouling using a thin film is possible if it is densely packed.

References

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Citations

Jan 10, 2013·Analytical Chemistry·Norman D BraultShaoyi Jiang
Jul 10, 2012·Chemical Society Reviews·Christophe BlaszykowskiMichael Thompson
Jul 29, 2015·Biomaterials Science·Christophe BlaszykowskiMichael Thompson
Jul 15, 2015·Advanced Materials Interfaces·King Hang Aaron LauPhillip B Messersmith
Jun 5, 2014·Journal of Biomaterials Science. Polymer Edition·Jheng-Fong JhongYung Chang
Jul 13, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Alexandra AubéJean-François Masson
May 17, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Yu-Ju ShihYu Chang
Mar 3, 2017·ACS Applied Materials & Interfaces·Daewha HongShaoyi Jiang
Nov 5, 2014·Advanced Materials·Qing Shao, Shaoyi Jiang
Mar 27, 2021·ACS Nano·Woojin ChoiJinkee Hong
Dec 8, 2017·ACS Applied Materials & Interfaces·Vivek YadavJacinta C Conrad
May 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Hyeongeun KangDaewha Hong
Aug 26, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·David L Cheung, King Hang Aaron Lau
Jun 9, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Ivana VíšováHana Vaisocherová-Lísalová

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