Dry-powder inhalers in acute asthma

Therapeutic Delivery
Olof Selroos

Abstract

An updated literature search was performed to evaluate the efficacy of rapid-acting β2-agonists delivered via dry powder inhalers in the treatment of moderate-to-severe acute asthma. Databases were searched from 1985 up to December 2012. A total of 23 randomized, double-blind or open clinical studies in acute asthma comparing the efficacy of a dry powder inhaler with a pressurized metered-dose inhaler or a nebulizer, and performed under controlled hospital conditions, were identified. This review found that administration of β2-agonist bronchodilators via dry powder inhalers (formoterol, salbutamol, terbutaline and budesonide/formoterol) was effective during severe asthma worsening and acute asthma attacks, and was as effective as established therapies with a pressurized metered-dose inhaler with or without a spacer, or nebulization. These results ensure that patients can rely upon dry powder inhalers equally well as other inhaler devices during episodes of asthma worsening.

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Citations

Nov 7, 2014·Expert Opinion on Drug Delivery·Anne H de Boer, Paul Hagedoorn
Sep 30, 2014·Pharmaceutical Development and Technology·Tan SuwandechaTeerapol Srichana
Jul 13, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Yasha LiangFengming Luo
May 28, 2020·Expert Opinion on Pharmacotherapy·Alessandro VatrellaCarolina Vitale
Oct 23, 2015·American Journal of Physiology. Cell Physiology·Elizabeth R PeitzmanScott M O'Grady

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