Drying Using Supercritical Fluid Technology as a Potential Method for Preparation of Chitosan Aerogel Microparticles

AAPS PharmSciTech
Rana M ObaidatMohammad Alnaief

Abstract

Supercritical fluid technology offers several advantages in preparation of microparticles. These include uniformity in particle size, morphology, and drug distribution without degradation of the product. One of the recent advantages is preparation of porous aerogel carrier with proper aerodynamic properties. In this study, we aimed to prepare chitosan aerogel microparticles using supercritical fluid (SCF) technology and compare that with microparticles produced by freeze drying (FD). Loading the prepared carriers with a model drug (salbutamol) was also performed. Comparisons of the particle properties and physicochemical characterizations were undertaken by evaluating particle size, density, specific surface area, and porosity. In vitro drug release studies were also investigated. The effect of many variables, such as molecular weight of chitosan oligomers, concentrations of chitosan, and concentrations of tripolyphosphate on the release, were also investigated. Chitosan aerogels were efficiently produced by SCF technology with an average particle size of 10 μm with a tapped density values around 0.12 g/mL, specific surface area (73-103) m(2)/g, and porosity (0.20-0.29) cc/g. Whereas, microparticles produced by FD method were c...Continue Reading

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Citations

Apr 27, 2016·AAPS PharmSciTech·Rana M ObaidatRana T Al Bustami
Jun 21, 2016·Advances in Colloid and Interface Science·Hajar MalekiMorteza Mahmoudi
Jul 29, 2017·Advanced Healthcare Materials·Ranjith Kumar KankalaAi-Zheng Chen
Jul 26, 2018·Materials·Imke PreibischIrina Smirnova
May 18, 2020·Pharmaceutics·Loredana Elena NitaAurica P Chiriac
Apr 10, 2020·Angewandte Chemie·Satoru TakeshitaMatthias M Koebel
Dec 2, 2020·Polymers·Tatiana BudtovaSytze J Buwalda
Jan 8, 2021·International Journal of Biological Macromolecules·Wei ShiCheng Hock Chuah
Feb 19, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carlos A García-GonzálezCarmen Alvarez-Lorenzo
Jun 1, 2021·Frontiers in Bioengineering and Biotechnology·Mariangela GuastaferroLucia Baldino
Jul 12, 2020·Current Drug Targets·Sina M MatalqahIslam Hamad

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