DSC, FTIR and Raman Spectroscopy Coupled with Multivariate Analysis in a Study of Co-Crystals of Pharmaceutical Interest

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Patrycja Garbacz, Marek Wesolowski

Abstract

Co-crystals have garnered increasing interest in recent years as a beneficial approach to improving the solubility of poorly water soluble active pharmaceutical ingredients (APIs). However, their preparation is a challenge that requires a simple approach towards co-crystal detection. The objective of this work was, therefore, to verify to what extent a multivariate statistical approach such as principal component analysis (PCA) and cluster analysis (CA) can be used as a supporting tool for detecting co-crystal formation. As model samples, physical mixtures and co-crystals of indomethacin with saccharin and furosemide with p-aminobenzoic acid were prepared at API/co-former molar ratios 1:1, 2:1 and 1:2. Data acquired from DSC curves and FTIR and Raman spectroscopies were used for CA and PCA calculations. The results obtained revealed that the application of physical mixtures as reference samples allows a deeper insight into co-crystallization than is possible with the use of API and co-former or API and co-former with physical mixtures. Thus, multivariate matrix for PCA and CA calculations consisting of physical mixtures and potential co-crystals could be considered as the most profitable and reliable way to reflect changes in s...Continue Reading

References

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Citations

Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iwona BudziakDaniel M Kamiński
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huahui ZengXiangxiang Wu
Apr 11, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rishi ThakkarMohammed Maniruzzaman

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Methods Mentioned

BETA
pharmacotherapy
X-ray
differential scanning calorimetry
PCA
co-crystallization

Software Mentioned

STARe
OMNIC
Statistica

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