DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system

Human Molecular Genetics
Kazuhiro YamakawaJulie R Korenberg

Abstract

Down syndrome (DS), a major cause of mental retardation, is characterized by subtle abnormalities of cortical neuroanatomy, neurochemistry and function. Recent work has shown that chromosome band 21q22 is critical for many of the neurological phenotypes of DS. A gene, DSCAM (Down syndrome cell adhesion molecule), has now been isolated from chromosome band 21q22.2-22.3. Homology searches indicate that the putative DSCAM protein is a novel member of the immunoglobulin (Ig) superfamily that represents a new class of neural cell adhesion molecules. The sequence of cDNAs indicates alternative splicing and predicts two protein isoforms, both containing 10 Ig-C2 domains, with nine at the N-terminus and the tenth located between domains 4 and 5 of the following array of six fibronectin III domains, with or without the following transmembrane and intracellular domains. Northern analyses reveals the transcripts of 9.7, 8.5 and 7.6 kb primarily in brain. These transcripts are differentially expressed in substructures of the adult brain. Tissue in situ hybridization analyses of a mouse homolog of the DSCAM gene revealed broad expression within the nervous system at the time of neuronal differentiation in the neural tube, cortex, hippocampu...Continue Reading

Citations

Jun 4, 2008·Archives of General Psychiatry·George R UhlCaryn Lerman
Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·R S Chapman, L J Hesketh
Dec 18, 2001·Journal of Neuroscience Research·K L AgarwalaK Yamakawa
Jan 29, 2011·Neuroscience Bulletin·Kun ZhuHaihong Ye
Sep 10, 2011·Protein & Cell·Yiliang XuJane Y Wu
May 15, 2013·Fish & Shellfish Immunology·Jingjing WangLinsheng Song
Aug 13, 2013·Fish & Shellfish Immunology·Hsin-Yi HungHan-Ching Wang
Oct 1, 2013·Trends in Neurosciences·Karen T ChangKyung-Tai Min
Jun 27, 2002·Biochemical and Biophysical Research Communications·Ryuichi NishigakiMitsuo Oshimura
Aug 5, 2000·Brain Research. Molecular Brain Research·K L AgarwalaK Yamakawa
Jun 8, 2007·Nature·S Sean MillardS Lawrence Zipursky
Jan 25, 2008·Nature·Peter G FuerstRobert W Burgess
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Guofa LiuJane Y Wu
Jul 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jan O KorbelJulie R Korenberg
Apr 12, 2008·Molecular Biology and Evolution·Daniela BritesLouis Du Pasquier
Apr 3, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·G M BarlowJ R Korenberg
Sep 24, 2005·Science·Aideen O'DohertyElizabeth M C Fisher
Oct 8, 2008·Annual Review of Cell and Developmental Biology·Daisuke HattoriS Lawrence Zipursky
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Jennifer L Ashurst, John E Collins
Feb 7, 2008·Cytogenetic and Genome Research·O Altug-TeberO Riess
Jul 8, 2011·Neural Computation·Elizabeth M ForbesGeoffrey J Goodhill
Aug 6, 2009·BMC Bioinformatics·Yiyuan SheHui Wang
Nov 10, 2010·BMC Bioinformatics·Hsun-Hsien ChangMarco F Ramoni
Apr 17, 2012·BMC Evolutionary Biology·Sophie A O ArmitageIgnacio G Bravo
Feb 18, 2006·BMC Evolutionary Biology·Mack E CraytonMorgan C Giddings
Oct 13, 2010·Molecular Brain·Scott Cameron, Yong Rao
Sep 30, 2009·Genome Biology·Sathyanath Rajasekharan, Timothy E Kennedy
Mar 10, 2009·Development·Megan M CortyWesley B Grueber
Oct 25, 2008·Development·Gracie L AndrewsThomas Kidd
May 17, 2012·PLoS Genetics·Clara Sze-Man TangMaria-Mercè Garcia-Barceló
Jun 23, 2011·PLoS Pathogens·Apiruck WatthanasurorotKenneth Söderhäll
Mar 10, 2001·Biochemical and Biophysical Research Communications·K L AgarwalaK Yamakawa
Apr 15, 2014·Developmental and Comparative Immunology·Tze Hann NgHan-Ching Wang
Aug 2, 2014·Developmental and Comparative Immunology·Tze Hann NgHan-Ching Wang

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