DSM-5 Attenuated Psychosis Syndrome in Adolescents Hospitalized With Non-psychotic Psychiatric Disorders

Frontiers in Psychiatry
Gonzalo Salazar de PabloChristoph U Correll

Abstract

Introduction: Although attenuated psychotic symptoms often occur for the first time during adolescence, studies focusing on adolescents are scarce. Attenuated psychotic symptoms form the criteria to identify individuals at increased clinical risk of developing psychosis. The study of individuals with these symptoms has led to the release of the DSM-5 diagnosis of Attenuated Psychosis Syndrome (APS) as a condition for further research. We aimed to characterize and compare hospitalized adolescents with DSM-5-APS diagnosis vs. hospitalized adolescents without a DSM-5-APS diagnosis. Methods: Interviewing help-seeking, hospitalized adolescents (aged 12-18 years) and their caregivers independently with established research instruments, we (1) evaluated the presence of APS among non-psychotic adolescents, (2) characterized and compared APS and non-APS individuals regarding sociodemographic, illness and intervention characteristics, (3) correlated psychopathology with levels of functioning and severity of illness and (4) investigated the influence of individual clinical, functional and comorbidity variables on the likelihood of participants to be diagnosed with APS. Results: Among 248 consecutively recruited adolescents (age=15.4 ± 1.5...Continue Reading

References

Dec 1, 1994·The American Journal of Psychiatry·S AgrawalK Kuruvilla
Feb 1, 1997·Community Mental Health Journal·H L Piersma, J L Boes
Dec 10, 1999·The Psychiatric Quarterly·T J MillerL Davidson
Dec 14, 2005·The Australian and New Zealand Journal of Psychiatry·Alison R YungJoe Buckby
Feb 8, 2006·Archives of General Psychiatry·Boris BirmaherMartin Keller
Nov 9, 2010·European Child & Adolescent Psychiatry·Celso Arango
Nov 26, 2010·Schizophrenia Research·Tim B ZiermansHerman van Engeland
Nov 21, 2012·JAMA Psychiatry·Paolo Fusar-PoliAlison Yung
Jan 22, 2013·BMJ : British Medical Journal·Megan R StaffordTim Kendall
Apr 12, 2013·Early Intervention in Psychiatry·Marko ManninenJaana Suvisaari
Jun 19, 2013·Schizophrenia Research·Ming T TsuangWilliam Carpenter
Sep 6, 2013·JAMA Psychiatry·Ricardo E CarriónBarbara A Cornblatt
Feb 7, 2014·JAMA Psychiatry·Ruben C GurRaquel E Gur
Jul 13, 2014·Schizophrenia Research·Maija LindgrenSebastian Therman
Apr 22, 2015·Schizophrenia Research·Marta Rapado-CastroBarnaby Nelson
Jun 5, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Benno G SchimmelmannFrauke Schultze-Lutter
Jun 6, 2015·The American Journal of Psychiatry·Barbara A CornblattChristoph U Correll
Jun 15, 2015·Psychiatry Research·Irina FalkenbergPaolo Fusar-Poli
Aug 25, 2015·Journal of the American Academy of Child and Adolescent Psychiatry·Maren CarbonChristoph U Correll
Sep 4, 2015·The British Journal of Psychiatry : the Journal of Mental Science·Paolo Fusar-PoliPhilip McGuire
Sep 27, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Paolo Fusar-PoliPhilip McGuire
Oct 7, 2015·Schizophrenia Research·Diana O PerkinsThomas H McGlashan
Apr 20, 2016·Journal of Child and Adolescent Psychopharmacology·Zainab Al-DhaherMaren Carbon
Apr 25, 2016·Schizophrenia Research·Emily KlineJason Schiffman

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01383915

Software Mentioned

AMDPS
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.