PMID: 7370771Apr 28, 1980Paper

DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats

Brain Research
G Jaim-Etcheverry, L M Zieher

Abstract

The pharmacological actions of the compound N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4) are compatible with a specific neurotoxic effect on both peripheral and central noradrenergic neurons. The systemic injection of DSP-4 to adult rats transiently alters sympathetic neurons in the periphery but in the central nervous system the compound determines a marked and prolonged reduction of noradrenaline (NA) levels in all brain regions studied. When DSP-4 was injected systemically to rats at birth in doses ranging from 6.25 to 100 micrograms/g, no changes were found in peripheral sympathetic neurons 40 days later. On the contrary, in the same conditions and in relation to the dose injected, there were marked and persistent changes in the levels of NA in different regions of the brain. In the cerebral cortex and the spinal cord, the neonatal injection of SDP-4 produced a marked and long-lasting depletion of NA levels, similar to that observed after injection of the compound to adult rats. These changes were accompanied by a moderate increase in brain stem NA and a marked elevation of the amine in the cerebellum. These changes, different from the depletion observed in both regions when the compound was given to a...Continue Reading

References

Jan 1, 1973·Annual Review of Pharmacology·H Thoenen, J P Tranzer
Jan 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P U Angeletti, R Levi-Montalcini
Jan 1, 1971·European Journal of Pharmacology·G Jaim-Etcheverry, L M Zieher
Jan 1, 1971·Neuropharmacology·P U Angeletti
Dec 15, 1958·Acta Physiologica Scandinavica·A BERTLERE ROSENGREN

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Citations

Apr 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·J S GutkindM A Enero
Jan 1, 1982·Journal of Neural Transmission·C Spyraki, H C Fibiger
Jun 3, 2008·Neurotoxicity Research·Przemyslaw NowakRyszard Brus
Feb 21, 2009·Neurochemical Research·Tommaso CassanoGabriella Gobbi
Feb 1, 1989·Biochemical Pharmacology·L P DwoskinN R Zahniser
Mar 19, 1986·Brain Research·S J Korn, R Dingledine
Sep 16, 1983·European Journal of Pharmacology·L M Zieher, G Jaim-Etcheverry
Apr 8, 1983·European Journal of Pharmacology·J H Medina, M L Novas
Feb 5, 1985·European Journal of Pharmacology·M DavisR L Commissaris
Jul 6, 1993·European Journal of Pharmacology·M OhnoS Watanabe
Dec 1, 1986·Experimental Neurology·G Carre, C Harley
Oct 1, 1986·Physiology & Behavior·T U JärbeT Archer
Aug 11, 1992·Physiology & Behavior·C A Cornwell-JonesK Kinnard
Feb 1, 1982·Pharmacology, Biochemistry, and Behavior·C SpyrakiH C Fibiger
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·Z A Bortolotto, E A Cavalheiro
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·A Agmo, Z Picker

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