PMID: 6989154Mar 1, 1980Paper

DTP and DTP-inactivated polio vaccines: comparison of adverse reactions and IGG, IGM and IGA antibody responses to DTP

Acta paediatrica Scandinavica
O RuuskanenT Peltonen


Adverse reactions and anti-DTP antibody responses were compared between DTP- or DTP-inactivated-polio-vaccinated children. The material consisted of 380 children whose adverse reactions were registered by detailed questionnaires given to the parents. IgG-, IgM- and IgA-anti-DTP antibodies of 42 children were quantified using enzyme-linked immunosorbent assay (ELISA). Fever, restlessness and local reactions were the most frequent adverse reactions observed. DTP-polio vaccine induced significantly more restlessness than DTP. This was the only significant difference in adverse reactions between the vaccines. An enhancement of IgG-anti-DTP antibody responses at the age of 6 months was observed in the DTP-polio group. The enhancement was transient in antitoxin responses but still present in pertussis antibodies at 8 months of age. Very low and mostly undetectable levels of IgM- and IgA-anti-DTP antibodies were observed in both groups.


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Related Concepts

Antibody Formation
Clinical Trials
Diphtheria toxoid vaccine, inactivated
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Pertussis Vaccine
Poliovirus Vaccine, Inactivated
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