DTPw-HB and Hib primary and booster vaccination: combined versus separate administration to Latin American children

Vaccine
José Ignacio SantosJoão Silva de Mendonça

Abstract

This multicentre study was designed to establish the reactogenicity and immunogenicity profiles of primary and booster vaccination with diphtheria, tetanus, and pertussis whole-cell-hepatitis B/Haemophilus influenzae type-b (DTPw-HB/Hib) administered as either a syringe mix or as separate injections in 400 Latin American children. Both vaccine regimens were equally well tolerated and elicited post-primary excellent seropositivity rates at or close to 100% for all five component antigens. With regard to HB, 100% of subjects in the combined vaccination group, and 98.8% subjects in the separate injection vaccination group reached seroprotective antibody concentrations (>or=10 mIU/ml) 1 month after the primary vaccination course. Equally high anti-PRP antibody concentrations were reached 1 month after vaccination, with 100% of seroprotected subjects in the combined vaccination group (antibody concentrations >or=0.15 microg/ml), against 99.4% in the separate injection vaccination group. Seroprotective anti-HBs and anti-PRP antibody concentration levels persisted approximately 1 year after the primary vaccination course, just prior to booster vaccination. Finally, a significant increase of all antibody concentrations could be observe...Continue Reading

References

Jul 1, 1994·The Pediatric Infectious Disease Journal·O Castillo de FebresK M Edwards
Mar 1, 1996·European Journal of Pediatrics·V UsonisP Vandepapeliere
Mar 7, 1998·Australian and New Zealand Journal of Public Health·M J FersonF Macartney-Bourne
Nov 23, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S A Halperin

❮ Previous
Next ❯

Citations

Jul 8, 2011·Science Translational Medicine·Guzman Sanchez-Schmitz, Ofer Levy
Mar 21, 2008·Expert Opinion on Biological Therapy·Roman Prymula, Stanislav Plisek
Dec 11, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Carlos Franco-ParedesJosé Ignacio Santos-Preciado
Aug 25, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Angkool KerdpanichKurt Dobbelaere
Aug 8, 2014·Memórias do Instituto Oswaldo Cruz·Griselda Escobedo-MelendezSonia Roman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Stella RiedemannHans L Bock
Revista Panamericana De Salud Pública = Pan American Journal of Public Health
Miguel TregnaghiLode Schuerman
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
J AristeguiHans L Bock
Revista Panamericana De Salud Pública = Pan American Journal of Public Health
Idis FaingezichtSue Ann Costa Clemens
© 2022 Meta ULC. All rights reserved