Du rire aux larmes: pathological laughing and crying in patients with traumatic brain injury and treatment with lamotrigine

Epilepsy & Behavior : E&B
L M Chahine, Z Chemali

Abstract

Pathologic laughter and crying (PLC) is the involuntary occurrence of laughter and crying in the absence of a corresponding change in affect. PLC resulting from structural brain damage in patients with traumatic brain injury can be the cause of substantial social dysfunction in these patients. The use of lamotrigine as an antiepileptic drug and mood stabilizer is well established; its use in PLC has been reported only once during treatment following a stroke. We present here four young patients with pathological laughter and/or pathological crying following traumatic brain injury who were successfully treated with lamotrigine. Data supporting the use of lamotrigine in the treatment of PLC following traumatic brain injury and the neuroanatomy of pathological laughing are briefly reviewed.

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Citations

Apr 8, 2014·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Edna Patatanian, Jessica Casselman
Jul 26, 2008·Neurologia Medico-chirurgica·Satoshi TsutsumiMasanori Ito
Feb 18, 2014·The Psychiatric Clinics of North America·David B Arciniegas, Hal S Wortzel
Mar 23, 2013·Neuroscience and Biobehavioral Reviews·Edward C LauterbachPreetha Sharone Kuppuswamy
Oct 28, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Tina MainkaChristos Ganos
Nov 3, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Peter Bede, Eoin Finegan

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