Dual Activity of Rose Bengal Functionalized to Albumin-Coated Lanthanide-Doped Upconverting Nanoparticles: Targeting and Photodynamic Therapy

ACS Applied Materials & Interfaces
Tarek SabriJohn A Capobianco

Abstract

A modified version of a desolvation method was used to render lanthanide-doped upconverting nanoparticles NaGdF4:Yb3+/Er3+ (Ln-UCNPs) water-dispersible and biocompatible for photodynamic therapy. Bovine serum albumin (BSA) was used as surface coating with a direct conjugation to NaGdF4:Yb3+/Er3+ nanoparticles forming a ∼2 nm thick shell. It was estimated that approximately 112 molecules of BSA were present and cross-linked per NaGdF4:Yb3+/Er3+ nanoparticle. Analysis of the BSA structural behavior on the Ln-UCNP surfaces displayed up to 80% loss of α-helical content. Modification of the Ln-UCNPs with a BSA shell prevents luminescence quenching from solvent molecules (H2O) with high energy vibrations that can interact with the excited states of the optically active ions Er3+ and Yb3+ via dipole-dipole interactions. Additionally, the photosensitizer rose bengal (RB) was conjugated to albumin on the surface of the Ln-UCNPs. Emission spectroscopy under 980 nm excitation was carried out, and an energy transfer efficiency of 63% was obtained. In vitro cell studies performed using human lung cancer cells (A549 cell line) showed that Ln-UCNPs coated with BSA were not taken by the cells. However, when RB was conjugated to BSA on the surf...Continue Reading

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Citations

Jun 5, 2019·Angewandte Chemie·Gabriella TessitoreJohn A Capobianco
Sep 24, 2019·Journal of Microencapsulation·Jing SunJing Wu
Jul 24, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wei WangYue-Yin Pan
Jan 31, 2019·ACS Applied Materials & Interfaces·Lile DongHongjie Zhang
Aug 8, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Michael S MeijerSylvestre Bonnet

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