Dual Ag/ZnO-Decorated Micro-/Nanoporous Sulfonated Polyetheretherketone with Superior Antibacterial Capability and Biocompatibility via Layer-by-Layer Self-Assembly Strategy

Macromolecular Bioscience
Yi DengZhi-Gang Chen

Abstract

Polyetheretherketone is attractive for dental and orthopedic applications due to its mechanical attributes close to that of human bone; however, the lack of antibacterial capability and bioactivity of polyetheretherketone has substantially impeded its clinical applications. Here, a dual therapy implant coating is developed on the 3D micro-/nanoporous sulfonated polyetheretherketone via layer-by-layer self-assembly of Ag ions and Zn ions. Material characterization studies have indicated that nanoparticles consisting of elemental Ag and ZnO are uniformly incorporated on the porous sulfonated polyetheretherketone surface. The antibacterial assays demonstrate that Ag-decorated sulfonated polyetheretherketone and Ag/ZnO-codecorated sulfonated polyetheretherketone effectively inhibit the reproduction of Gram-negative and Gram-positive bacteria. Owing to the coordination of micro-/nanoscale topological cues and Zn induction, the Ag/ZnO-codecorated sulfonated polyetheretherketone substrates are found to enhance biocompatibility (cell viability, spreading, and proliferation), and hasten osteodifferentiation and -maturation (alkaline phosphate activity (ALP) production, and osteogenesis-related genetic expression), compared with the Ag-d...Continue Reading

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Citations

Oct 12, 2018·Journal of Biomaterials Science. Polymer Edition·Li-Jun DengYi Deng
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yulin JiangLi Zhang
Sep 10, 2020·International Journal of Nanomedicine·Yuehong LiYanguo Qin
Feb 14, 2021·Stem Cell Research & Therapy·Siyi WangYunsong Liu
Jan 30, 2021·Frontiers in Bioengineering and Biotechnology·Xinming GuYanmin Zhou

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