Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL.

Journal of Clinical Immunology
Kyra Oswald-RichterWonder P Drake

Abstract

Sarcoidosis is a non-caseating granulomatous disease for which a role for infectious antigens continues to strengthen. Recent studies have reported molecular evidence of mycobacteria or propionibacteria. We assessed for immune responses against mycobacterial and propionibacterial antigens in sarcoidosis bronchoalveolar lavage (BAL) using flow cytometry, and localized signals consistent with microbial antigens with sarcoidosis specimens, using matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS). BAL cells from 27 sarcoidosis, 14 PPD- controls, and 9 subjects with nontuberculosis mycobacterial (NTM) infections were analyzed for production of IFN-γ after stimulation with mycobacterial ESAT-6 and Propionibacterium acnes proteins. To complement the immunological data, MALDI-IMS was performed to localize ESAT-6 and Propionibacterium acnes signals within sarcoidosis and control specimens. CD4+ immunologic analysis for mycobacteria was positive in 17/27 sarcoidosis subjects, compared to 2/14 PPD- subjects, and 5/9 NTM subjects (p = 0.008 and p = 0.71 respectively, Fisher's exact test). There was no significant difference for recognition of P. acnes, which occurred only in sarcoidosis subjects that also rec...Continue Reading

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Citations

Oct 18, 2012·Journal of Clinical Immunology·Bradley W RichmondWonder P Drake
May 14, 2014·American Journal of Clinical Dermatology·Karolyn A Wanat, Misha Rosenbach
Jul 30, 2014·American Journal of Respiratory and Critical Care Medicine·Nicole A BraunWonder P Drake
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May 28, 2014·Australian Dental Journal·M H MotswalediL Feller
Jul 6, 2015·Dermatologic Clinics·Miguel SanchezSteve Prystowsky
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Jul 6, 2014·Current Opinion in Microbiology·Jessica L MooreEric P Skaar
Nov 12, 2014·Frontiers in Pharmacology·Sabine RingkowskiCristan Herbert
Jan 13, 2015·Immunotherapy·Lindsay J Celada, Wonder P Drake
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May 18, 2016·Proteomics. Clinical Applications·Rémi LonguespéeEdwin De Pauw
Mar 4, 2017·The Journal of Dermatology·Jun Asai
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Nov 30, 2016·BMC Pulmonary Medicine·Tiago EstevesVicente Garcia-Patos
Jun 12, 2019·Journal of Biomedical Science·Pleiades T InaokaJ Luis Espinoza
May 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyra A Oswald-RichterWonder P Drake
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Jul 31, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Manu N CapoorOndrej Slaby
Jan 26, 2021·Expert Review of Clinical Pharmacology·Ogugua Ndili ObiRobert P Baughman
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