Dual ANCA positivity in subacute bacterial endocarditis

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
Alexandra M Tiliakos, Nicholas A Tiliakos

Abstract

Nine cases of subacute bacterial endocarditis (SBE) associated with anti-PR3 ANCA have been described in the literature to date. We describe 2 cases of SBE associated with dual ANCA positivity (anti-PR3 and anti-MPO ANCA.) To our knowledge, these are the first such reported cases. One case was associated with cutaneous vasculitis, and the second with predisposing factors for SBE. ANCA titers resolved or decreased in both during initial corticosteroid therapy for suspected vasculitis. Follow-up of these patients revealed no evidence of the common ANCA associations such as Wegener granulomatosis. Rheumatologists, if aware of ANCA association with SBE, can avoid inappropriate immunosuppressive treatments.

References

Jun 28, 2002·Cleveland Clinic Journal of Medicine·Gloria A PrestonRonald J Falk
Jun 28, 2002·Cleveland Clinic Journal of Medicine·Ulrich Specks
May 8, 2003·Heart & Lung : the Journal of Critical Care·André de Corla-Souza, Burke A Cunha

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Citations

Jan 1, 2011·BMJ Case Reports·Stefanie Christina RobertJulia S Hadley
Jan 1, 2011·BMJ Case Reports·Stefanie Christina RobertJulia S Hadley
Jun 19, 2014·Pathology, Research and Practice·Jennifer A CollinsAllen P Burke
Jan 22, 2015·Kidney International·Christie L BoilsChristopher P Larsen
Jul 2, 2016·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Fareed B Kamar, T Lee-Ann Hawkins
Mar 10, 2012·Scandinavian Journal of Rheumatology·C AgardM Hamidou
Nov 9, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Anjali A SatoskarTibor Nadasdy
Jan 31, 2017·La Revue de médecine interne·V Langlois, I Marie
Feb 16, 2012·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Rafael BojalilLuis M Amezcua-Guerra
Aug 11, 2019·Nature Reviews. Nephrology·Anjali A SatoskarTibor Nadasdy
Mar 8, 2020·Journal of Clinical Medicine·Pauline CaillardDimitri Titeca-Beauport

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