Dual-axis hormonal covariation in adolescence and the moderating influence of prior trauma and aversive maternal parenting

Developmental Psychobiology
Julian G SimmonsNicholas B Allen

Abstract

Adversity early in life can disrupt the functioning of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes and increase risk for negative health outcomes. The interplay between these axes and the environment is complex, and understanding needs to be advanced by the investigation of the multiple hormonal relationships underlying these processes. The current study examined basal hormonal associations between morning levels of cortisol, testosterone, and dehydroepiandrosterone in a cohort of adolescents (mean age 15.56 years). The moderating influence of childhood adversity was also examined, as indexed by self-reported trauma (at mean age 14.91), and observed maternal aggressive parenting (at mean age 12.41). Between-person regressions revealed significant associations between hormones that were moderated by both measures of adversity. In females, all hormones positively covaried, but also interacted with adversity, such that positive covariation was typically only present when levels of trauma and/or aggressive parenting were low. In males, hormonal associations and interactions were less evident; however, interactions were detected for cortisol-testosterone - positively covarying at high levels of aggress...Continue Reading

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Citations

Jun 30, 2015·Developmental Psychobiology·Andrew R DismukesSeth D Pollak
Jul 30, 2015·Developmental Psychobiology·Elizabeth A ShirtcliffGeorges Han
Jan 27, 2015·Psychoneuroendocrinology·Despina E GanellaSarah Whittle
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Aug 21, 2018·Annual Review of Psychology·Bruce J Ellis, Marco Del Giudice
Jun 21, 2017·Stress : the International Journal on the Biology of Stress·Marcus K TaylorPaul Sargent
Jul 11, 2020·Hormones and Behavior·Mariann A HowlandMegan R Gunnar

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