Dual-coated lactic acid bacteria: an emerging innovative technology in the field of probiotics

Future Microbiology
Guillermo Alvarez-Calatayud, Abelardo Margolles

Abstract

Probiotics are living micro-organisms that do not naturally have shelf life, and normally are weakly protected against the digestive action of the GI tract. A new dual coating technology has been developed in an effort to maximize survival, that is, to be able to reach the intestine alive and in sufficient numbers to confer the beneficial health effects on the host. Dual-coating of lactic acid bacteria (LAB) is the result of fourth-generation coating technology for the protection of these bacteria at least 100-fold or greater than the uncoated LAB. This innovative technique involves a first pH-dependent protein layer that protects bacteria from gastric acid and bile salt, and a second polysaccharide matrix that protects bacteria from external factors, such as humidity, temperature and pressure, as well as the digestive action during the passage through the GI tract. Dual-coated probiotic formulation is applicable to different therapeutic areas, including irritable bowel syndrome, atopic dermatitis, acute diarrhea, chronic constipation, Helicobacter pylori eradication, and prevention of antibiotic-associated diarrhea. An updated review of the efficacy of doubly coated probiotic strains for improving bacterial survival in the int...Continue Reading

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Citations

Jun 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sanja KolačekUNKNOWN ESPGHAN Working Group for Probiotics and Prebiotics
Jun 8, 2017·Frontiers in Microbiology·Xiang-Dong WuWei Huang
May 4, 2021·Food Science and Biotechnology·Basavaprabhu H NatarajPradip V Behare
Oct 26, 2018·Advanced Drug Delivery Reviews·A BakD J Brayden

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