Dual contrast in computed tomography allows earlier characterization of articular cartilage over single contrast

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Abhisek BhattaraiJuha Töyräs

Abstract

Cationic computed tomography contrast agents are more sensitive for detecting cartilage degeneration than anionic or non-ionic agents. However, osteoarthritis-related loss of proteoglycans and increase in water content contrarily affect the diffusion of cationic contrast agents, limiting their sensitivity. The quantitative dual-energy computed tomography technique allows the simultaneous determination of the partitions of iodine-based cationic (CA4+) and gadolinium-based non-ionic (gadoteridol) agents in cartilage at diffusion equilibrium. Normalizing the cationic agent partition at diffusion equilibrium with that of the non-ionic agent improves diagnostic sensitivity. We hypothesize that this sensitivity improvement is also prominent during early diffusion time points and that the technique is applicable during contrast agent diffusion. To investigate the validity of this hypothesis, osteochondral plugs (d = 8 mm, N = 33), extracted from human cadaver (n = 4) knee joints, were immersed in a contrast agent bath (a mixture of CA4+ and gadoteridol) and imaged using the technique at multiple time points until diffusion equilibrium. Biomechanical testing and histological analysis were conducted for reference. Quantitative dual-ener...Continue Reading

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Citations

Aug 9, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Abhisek BhattaraiMikael J Turunen
Sep 26, 2020·Frontiers in Cell and Developmental Biology·Mateus Oliveira SilvaKathryn S Stok

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