Dual cross-linked pulsatile beads for chronotherapy of asthma: development and evaluation

Drug Delivery
Avinash Tekade, Surendra G Gattani

Abstract

In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Theophylline dual-cross-linked beads were prepared by dropping dispersed phase of theophylline, Delonix regia gum (DRG), and sodium alginate into the dispersion phase of different concentration of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1:2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5–7 h before release of theophylline from the formulated beads, which were found to be intact for 6 h. Thus, formulated dual cross-linked beads when administered at bed time may release theophylline when needed most for chronotherapeutics of early morning asthmatic attacks in chronic patients. In vivo radio imaging study carried out in New Zealand white strain rabbit confirms the findings of in vitro results.

References

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Sep 3, 2002·International Journal of Pharmaceutics·Kang Wang, Zhimin He
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·P Ferreira Almeida, A J Almeida
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Oct 19, 2006·International Journal of Pharmaceutics·Thaned Pongjanyakul, Satit Puttipipatkhachorn
Feb 25, 2009·Pharmaceutical Development and Technology·Avinash R Tekade, Surendra G Gattani

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Citations

Mar 5, 2013·Current Neurology and Neuroscience Reports·Sriram RamgopalTobias Loddenkemper
Nov 29, 2011·Expert Opinion on Drug Delivery·Dali ShuklaBrahmeshwar Mishra
Mar 31, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Sunil K JainKuldeep Rajpoot
Jul 28, 2020·Frontiers in Neurology·Christopher J ReThomas N Ferraro
Jan 11, 2019·Neuroscience and Biobehavioral Reviews·Daniel Leite Góes GitaiAshok K Shetty

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