Dual deep neural network-based classifiers to detect experimental seizures

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Hyun-Jong Jang, Kyung-Ok Cho

Abstract

Manually reviewing electroencephalograms (EEGs) is labor-intensive and demands automated seizure detection systems. To construct an efficient and robust event detector for experimental seizures from continuous EEG monitoring, we combined spectral analysis and deep neural networks. A deep neural network was trained to discriminate periodograms of 5-sec EEG segments from annotated convulsive seizures and the pre- and post-EEG segments. To use the entire EEG for training, a second network was trained with non-seizure EEGs that were misclassified as seizures by the first network. By sequentially applying the dual deep neural networks and simple pre- and post-processing, our autodetector identified all seizure events in 4,272 h of test EEG traces, with only 6 false positive events, corresponding to 100% sensitivity and 98% positive predictive value. Moreover, with pre-processing to reduce the computational burden, scanning and classifying 8,977 h of training and test EEG datasets took only 2.28 h with a personal computer. These results demonstrate that combining a basic feature extractor with dual deep neural networks and rule-based pre- and post-processing can detect convulsive seizures with great accuracy and low computational bur...Continue Reading

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
May 1, 1995·Electroencephalography and Clinical Neurophysiology·G AlarconC E Polkey
Nov 1, 2000·Journal of Medical Systems·M Akin, M K Kiymik
Dec 5, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Scott B Wilson, Ronald Emerson
Jul 12, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·T DikanevB Bezruchko
Dec 6, 2007·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Hamid R MohseniMohammad B Shamsollahi
Feb 28, 2008·Computational Intelligence and Neuroscience·A T TzallasD I Fotiadis
Oct 7, 2008·Epilepsy & Behavior : E&B·Asla Pitkänen, Katarzyna Lukasiuk
Jul 28, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A AarabiY Aghakhani
May 4, 2010·Journal of Medical Systems·D Puthankattil SubhaChoo Min Lim
Dec 7, 2011·Epilepsy & Behavior : E&B·Ivan OsorioDidier Sornette
Oct 9, 2012·Epilepsy & Behavior : E&B·James R WilliamsonJaishree T Narayanan
May 1, 2013·International Journal of Neural Systems·U Rajendra AcharyaJasjit S Suri
Jul 27, 2014·Epilepsy Research·Yanli ZhangQi Wu
Feb 25, 2015·Nature Neuroscience·Brian P Grone, Scott C Baraban
Apr 9, 2015·Frontiers in Computational Neuroscience·Dragoljub GajicIvana Savic-Gajic
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
Sep 4, 2015·Cold Spring Harbor Perspectives in Medicine·Joseph I Sirven
Dec 22, 2017·Australasian Physical & Engineering Sciences in Medicine·Abeg Kumar Jaiswal, Haider Banka
May 25, 2018·Neural Networks : the Official Journal of the International Neural Network Society·Nhan Duy TruongOmid Kavehei

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Citations

Feb 15, 2020·Sensors·Beanbonyka RimMin Hong
May 30, 2019·Archives of Pharmacal Research·Hyun-Jong Jang, Kyung-Ok Cho
Sep 29, 2020·Journal of Epilepsy Research·Sora AnHyang Woon Lee
Jan 8, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kyung-Ok ChoHyun-Jong Jang
Feb 24, 2021·Disease Models & Mechanisms·Grant F MarshallCatherine M Abbott
Oct 5, 2021·Journal of Neural Engineering·Lan WeiCatherine Mooney

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Methods Mentioned

BETA
feature extraction
PCR

Software Mentioned

TensorFlow

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