PMID: 6107675Nov 8, 1980Paper

Dual diagnosis of prenatal haemophilia A by measurement of fetal factor VIIIC and VIIIC antigen (VIIICAg)

Lancet
R S MibashanA L Bloom

Abstract

Procoagulant factor VIII (VIIIC) and procoagulant factor VIII antigen (VIIICAg) were measured in 20 samples of pure fetal blood obtained by fetoscopy at mid-term from non-haemophilic fetuses. VIIIC levels ranged from 25 to 89 U/dl (mean 43.5) and VIIICAg from 11 to 43 U/dl (mean 22.3). Samples from 39 consecutive fetuses at risk of haemophilia A gave results indicating haemophilia in 11, and these pregnancies were terminated at the parents' request. Of the remaining 28, 18 have resulted in normal births, 8 still await delivery, and 2 pregnancies were terminated for non-haematological reasons. The results confirm that pure fetal blood can be aspirated fetoscopically for plasma assays of both VIIIC and VIIICAg. Dual measurement enhances the reliability of predicting or excluding haemophilia A, and makes prenatal diagnosis a dependable option for known or potential carriers seeking this information.

References

Nov 1, 1978·The Journal of Clinical Investigation·J Lazarchick, L W Hoyer
Sep 22, 1979·Lancet·C H RodeckA L Bloom
Jan 1, 1979·Thrombosis Research·H M ReisnerJ B Graham
Apr 26, 1979·The New England Journal of Medicine·S I FirsheinM J Mahoney
Sep 9, 1978·British Medical Journal·C H Rodeck, S Campbell
Jan 1, 1971·The Journal of Clinical Investigation·T S ZimmermanA S Littell

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Citations

Oct 3, 1985·The New England Journal of Medicine·S E AntonarakisD N Fass
Aug 1, 1997·The Journal of Obstetrics and Gynaecology Research·Y H YangD H Cha
Jun 1, 1997·Haemophilia : the Official Journal of the World Federation of Hemophilia·D I Evans
May 1, 1984·The Australian & New Zealand Journal of Obstetrics & Gynaecology·C H Rodeck
Nov 1, 1985·Prenatal Diagnosis·D S MillarR S Mibashan
Jan 1, 1982·Annals of the New York Academy of Sciences·E A Jaffe
Mar 27, 2007·Sociology of Health & Illness·Camilla Zimmermann
Jan 1, 1991·Annals of the New York Academy of Sciences·J Gitschier
Jan 15, 1987·Klinische Wochenschrift·T L BoehmD Drahovsky

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