Dual drug loaded chitosan nanoparticles-sugar--coated arsenal against pancreatic cancer

Colloids and Surfaces. B, Biointerfaces
Karolyn Infanta DavidUma Maheswari Krishnan

Abstract

Pancreatic cancer is an aggressive form of cancer with poor survival rates. The increased mortality due to pancreatic cancer arises due to many factors such as development of multidrug resistance, presence of cancer stem cells, development of a stromal barrier and a hypoxic environment due to hypo-perfusion. The present study aims to develop a nanocarrier for a combination of drugs that can address these multiple issues. Quercetin and 5-fluorouracil were loaded in chitosan nanoparticles, individually as well as in combination. The nanoparticles were characterized for morphology, size, zeta potential, percentage encapsulation of drugs as well as their release profiles in different media. The dual drug-loaded carrier exhibited good entrapment efficiency (quercetin 95% and 5-fluorouracil 75%) with chitosan: quercetin: 5-fluorouracil in the ratio 3:1:2. The release profiles suggest that 5-fluorouracil preferentially localized in the periphery while quercetin was located towards the core of chitosan nanoparticles. Both drugs exhibited considerable association with the chitosan matrix. The dual drug-loaded carrier system exhibited significant toxicity towards pancreatic cancer cells both in the 2D as well as in the 3D cultures. We be...Continue Reading

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Citations

Jan 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ju-Suk NamSang-Soo Lee
Apr 17, 2016·Carbohydrate Polymers·Sávia Francisca Lopes DiasDurcilene Alves da Silva
Feb 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Justina Roxana VirlanMaria Greabu
Oct 17, 2019·Experimental Biology and Medicine·Jennifer S WinklerMaria S Tomassone
Feb 15, 2020·IUBMB Life·Fatemeh SadoughiSeyyed Mehdi Mirhashemi
Feb 6, 2017·Drug Delivery·Orazio VittorioGiuseppe Cirillo
Aug 18, 2020·International Journal of Nanomedicine·Xuan ZhuChunlin Ge
Oct 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Umeorah ErnestGhulam Murtaza
Jun 4, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Yingying ChaiZhimin He

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