Dual dynamics of mitochondrial permeability transition pore opening.

Scientific Reports
Benjamin WacquierGeneviève Dupont

Abstract

Mitochondria play an essential role in bioenergetics and cellular Ca[Formula: see text] handling. The mitochondrial permeability transition pore (mPTP) is a non-specific channel located in the inner mitochondrial membrane. Long-lasting openings of the pore allow the rapid passage of ions and large molecules, which can result in cell death. The mPTP also exhibits transient, low conductance openings that contribute to Ca[Formula: see text] homeostasis. Although many regulators of the pore have been identified, none of them uniquely governs the passage between the two operating modes, which thus probably relies on a still unidentified network of interactions. By developing a core computational model for mPTP opening under the control of mitochondrial voltage and Ca[Formula: see text], we uncovered the existence of a positive feedback loop leading to bistability. The characteristics of the two stable steady-states correspond to those of the two opening states. When inserted in a full model of Ca[Formula: see text] handling by mitochondria, our description of the pore reproduces observations in mitochondrial suspensions. Moreover, the model predicted the occurrence of hysteresis in the switching between the two modes, upon addition ...Continue Reading

References

Jul 1, 1979·Archives of Biochemistry and Biophysics·R A Haworth, D R Hunter
Jul 1, 1979·Archives of Biochemistry and Biophysics·D R Hunter, R A Haworth
Jul 1, 1979·Archives of Biochemistry and Biophysics·D R Hunter, R A Haworth
Aug 1, 1989·Journal of Bioenergetics and Biomembranes·K W KinnallyH Tedeschi
Jul 17, 1995·Biochimica Et Biophysica Acta·M Zoratti, I Szabò
Aug 1, 1997·The American Journal of Physiology·G Magnus, J Keizer
Apr 17, 1998·Biophysical Journal·J HüserL A Blatter
Oct 28, 1998·Nature·M J BerridgeP Lipp
Apr 3, 2002·The EMBO Journal·Tony J CollinsMartin D Bootman
Apr 2, 2003·Biophysical Journal·Sonia CortassaBrian O'Rourke
Jun 26, 2003·European Journal of Biochemistry·Lars F OlsenUrsula Kummer
Oct 14, 2003·The Journal of Physiology·Sheila L Dargan, Ian Parker
Jul 25, 2006·Journal of Theoretical Biology·Alexandra V PokhilkoEkhson L Holmuhamedov
Sep 2, 2006·Journal of Theoretical Biology·Richard BertramArthur Sherman
May 6, 2009·Biochimica Et Biophysica Acta·Richard M Denton
Mar 13, 2010·BMC Research Notes·Sabine EisenhoferHans Zischka
Jun 12, 2010·Journal of Theoretical Biology·Jason N BazilAnn E Rundell
Dec 7, 2011·PloS One·Guillaume Azarias, Jean-Yves Chatton
Oct 16, 2012·Circulation Research·Catherine Brenner, Maryline Moulin
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Valentina GiorgioPaolo Bernardi
Jan 19, 2016·Scientific Reports·Benjamin WacquierGeneviève Dupont
Aug 9, 2016·Journal of Bioenergetics and Biomembranes·Stephen HurstShey-Shing Sheu
Dec 28, 2016·PLoS Biology·Mitra MojtahediSui Huang
May 20, 2017·Cell Calcium·Valentina GiorgioPaolo Bernardi
Oct 22, 2017·The FEBS Journal·Benjamin WacquierGeneviève Dupont
Dec 8, 2017·Journal of Cellular Physiology·Xavier Chapa-DubocqSabzali Javadov
Mar 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir I MakarovSabzali Javadov
Aug 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Rosa Martinez-CorralJordi Garcia-Ojalvo
Feb 19, 2019·Frontiers in Genetics·Elaina M MaldonadoShamima Rahman
May 14, 2019·Current Protocols in Pharmacology·Gauri Bhosale, Michael R Duchen
Jun 15, 2019·FEBS Letters·Michela CarraroPaolo Bernardi

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Citations

Jul 25, 2021·Chemico-biological Interactions·Isaac J BelloOlufunso O Olorunsogo
Aug 22, 2021·Biophysical Chemistry·Igor Khmelinskii, Vladimir Makarov
Oct 26, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Danielle van der WesthuizenOrde Q Munro

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