Dual effect biodegradable ciprofloxacin loaded implantable matrices for osteomyelitis: controlled release and osteointegration

Drug Development and Industrial Pharmacy
Ahmed F HanafyEl-Sayed E Habib

Abstract

Ciprofloxacin biodegradable implantable matrices (CPX-IMs) of tailored porous surfaces were fabricated by hot melt injection molding of poly-l-lactic acid (PLLA) followed by coating with PLLA/sodium chloride. CPX-IDs were designed to have a non-porous coat (NPC) or a porous coat of small pore size (SPC; 150-250 µm) or a large pore size (LPC; 250-350 µm). CPX-IMs surface pore size was confirmed by scanning electron microscope. The hardness of NPC, LPC, and SPC CPX-IMs were 58 ± 2.8, 53 ± 1.9, and 50 ± 2.1 N, respectively. The measured porosity values were 41.2 ± 1.53, 65.2 ± 1.1, and 60.7 ± 1.2%, respectively. Differential scanning calorimetry was employed to study the compatibility of ingredients, the effect of injection molding on polymer properties, and implants degradation. Coating of CPX-IMs prolonged drug release to reach a value of 90% release in 40 days. Antibacterial activity tests showed sufficiency of CPX to inhibit pathogens known to cause osteomyelitis. The in vivo study showed tissue compatibilities of the inserted matrices in tested rats with no sign of infection throughout the experiment period. SPC and LPC CPX-IMs demonstrated a better osteointegration, cell adhesion, and infiltration of different types of bone ...Continue Reading

References

Nov 1, 1991·The Veterinary Clinics of North America. Food Animal Practice·A M Trent, D Plumb
Sep 2, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Rothen-WeinholdR Gurny
Aug 27, 2002·Biomaterials·Friederike von BurkersrodaAchim Göpferich
Oct 24, 2002·Neurological Research·Hun K ParkMurali Guthikonda
Dec 4, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·C CastroC Evora
Apr 15, 2004·International Journal of Pharmaceutics·Kathleen DillenAnnick Ludwig
Oct 16, 2004·The New England Journal of Medicine·Werner ZimmerliPeter E Ochsner
Jul 6, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C CastroE Sánchez
Oct 20, 2006·Bone·Yoshiyuki NemotoYoshiro Takano
Oct 30, 2009·International Journal of Molecular Sciences·SuPing Lyu, Darrel Untereker
Dec 25, 2010·International Journal of Pharmaceutics·Luciana Lisa LaoSubbu S Venkatraman
Feb 12, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jessica A LyndonNick Birbilis
Mar 25, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Y S LiuQ L Feng
Jun 29, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Soumyaranjan MohantyAnders Wolff
Apr 30, 2016·Advanced Drug Delivery Reviews·Marco SantoroAntonios G Mikos
Aug 16, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Azadeh MoteallehPedro Miranda
Oct 19, 2016·Journal of Shoulder and Elbow Surgery·Jennica J TuckerLouis J Soslowsky
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Muhammad Shoaib ButtGuanghong Zhou
Jan 11, 2017·Journal of the Mechanical Behavior of Biomedical Materials·F ToptanP Ponthiaux
Sep 1, 2010·Comprehensive Reviews in Food Science and Food Safety·Majid JamshidianStéphane Desobry

❮ Previous
Next ❯

Citations

Aug 1, 2019·Biomaterials Science·Anastasiia KashirinaJinsong Leng
Nov 18, 2020·International Journal of Molecular Sciences·Jeong-Hyun RyuJae-Sung Kwon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Hao GaoYueqing Gu
Journal of Biomedical Materials Research. Part a
Shanta Raj BhattaraiHak Yong Kim
Journal of Biomaterials Applications
A G AndreopoulosK Kanellakopoulou
Materials Science & Engineering. C, Materials for Biological Applications
K Sangeetha, E K Girija
© 2022 Meta ULC. All rights reserved