PMID: 5701May 6, 1976

Dual effect of 2,3-diphosphoglycerate on the Bohr effects of human blood

Pflügers Archiv : European journal of physiology
Jochen Duhm


The influence of the red cell concentration of 2,3-diphosphoglycerate (2,3-DPG, 0.5-26 mumoles/g erythrocytes) on the "CO2-Bohr effect" (pH varied by CO2 at constant base excess) and the "fixed acid-Bohr effect" (pH varied by fixed acid or base at constant PCO2) was studied in human blood at plasma pH values ranging between pH 7.2 and pH 7.6. Elevation of red cell 2,3-DPG concentration leads to a numerical decrease of the "CO2-Bohr coefficient" referring to plasma pH. The "fixed acid-Bohr coefficients" are numerically smaller than the corresponding "CO2-Bohr coefficients" and exhibit a maximum at normal red cell 2,3-DPG concentrations. The Bohr coefficients referring to red cell pH are distinctly higher than those referring to plasma pH, especially at high 2,3-DPG levels. This is due on the one hand to the physico-chemical properties of the intact red cell membrane, and on the other hand to a 2,3-DPG-induced decrease in the ratio deltapHcell/deltapHplasma. From the results it is concluded that 2,3-DPG exerts a dual effect on the Bohr coefficients of whole blood which is mediated 1. by the direct effect of 2,3-DPG on the allosteric properties of hemoglobin (as reflected by changes of the Bohr coefficients referring to red cell p...Continue Reading


May 6, 1976·Pflügers Archiv : European journal of physiology·Jochen Duhm
Jun 1, 1975·Journal of Applied Physiology·M P Hlastala, R Woodson
Sep 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·G ArtursonB Zaar
Jan 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·O Siggaard-Andersen, L Garby
Oct 1, 1973·Respiration Physiology·A A Messier, K E Schaefer
Mar 1, 1974·Acta paediatrica Scandinavica·V Andersen, E Andersen
May 7, 1974·Biochemical and Biophysical Research Communications·S H de BruinG A van Os
Apr 1, 1972·Acta Physiologica Scandinavica·L GarbyB Zaar
Apr 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·O Siggaard-AndersenM Rörth
Jun 1, 1972·Journal of Applied Physiology·B WranneJ Detter
Jan 1, 1972·Advances in Experimental Medicine and Biology·B WranneJ Detter
Sep 17, 1971·Biochemical and Biophysical Research Communications·P R CaldwellE R Jaffe
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A Riggs
Mar 15, 1971·Experientia·P BattagliaS Passi
Jun 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·O Siggaard-Andersen, N Salling
May 1, 1966·Journal of Applied Physiology·J W Severinghaus
Jan 1, 1966·Scandinavian Journal of Clinical and Laboratory Investigation·N NAERAAJ W Severinghaus
Jan 1, 1962·Scandinavian Journal of Clinical and Laboratory Investigation·O S ANDERSENN NAERAA
Aug 1, 1963·The American Journal of Physiology·P HILPERTH BARTELS
Jan 1, 1964·Advances in Protein Chemistry·J WYMAN
Mar 1, 1960·The Journal of General Physiology·A Riggs


Nov 14, 1978·Pflügers Archiv : European journal of physiology·J P WeingartenP Scheid
Sep 29, 1978·Pflügers Archiv : European journal of physiology·M MeyerP Scheid
May 6, 1976·Pflügers Archiv : European journal of physiology·Jochen Duhm
Jan 1, 1985·Respiration Physiology·L A Maginniss
Aug 1, 1991·Respiration Physiology·D BöningS Göke
Oct 1, 1995·Respiration Physiology·F R RagsdaleR L Ingermann
Dec 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·C F Cartheuser
Jun 1, 1987·Blut·D Böning, G Enciso
Sep 1, 1982·The American Journal of the Medical Sciences·S CarloneF Manfredi
May 1, 1987·Respiration Physiology·W SchmidtK M Braumann
Feb 13, 1990·Biochemistry·I LalezariM F Perutz
Oct 23, 2002·Journal of Applied Physiology·Richard SerianniPaul D Mongan
Jan 1, 1979·CRC Critical Reviews in Clinical Laboratory Sciences·R Juel

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