PMID: 3246Feb 1, 1976Paper

Dual effect of alpha-adrenoceptor antagonists in rat isolated vas deferens

British Journal of Pharmacology
A Jurkiewicz, N H Jurkiewicz

Abstract

1 In rat isolated vas deferens, the isotonic contractile responses to low doses of noradrenaline or adrenaline were antagonized, and those to high doses were potentiated, by yohimbine, piperoxan, phentolamine and tolazoline. Effects due to intermediate doses were not affected, or were potentiated within about 30 min, following an initial inhibition. 2 The alpha-adrenoceptor blockers thus caused a shift to the right and an increase of the maximum height of log dose-response curves of alpha-adrenoceptor stimulants. For a given dose of antagonist, the onset was slower for the potentiating than for the blocking effect. 3 The shift to the right induced by piperoxan and yohimbine on dose-response curves of noradrenaline and adrenaline was analysed with the Schild plot, and the slopes obtained, around 0.3, were lower than expected from receptor theory. When cocaine was used to block neuronal uptake, the slopes were close to 1.0. 4 The increase in maximum response to noradrenaline and adrenaline induced by alpha-adrenoceptor blockers was dependent on the time of incubation, on the dose of antagonist, and on the initial height of responses to the agonist. A less pronounced potentiation was also obtained when acetylcholine was used as ag...Continue Reading

References

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Citations

May 17, 2014·Life Sciences·Guilherme Henrique Souza BomfimNeide Hyppolito Jurkiewicz
Apr 17, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Edilson Dantas da Silva JúniorNeide H Jurkiewicz
Nov 1, 1993·British Journal of Pharmacology·F OralloM I Cadavid
Jul 4, 1996·European Journal of Pharmacology·N H JurkiewiczA Jurkiewicz
Mar 29, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Guiomar Silva LopesNeide Hyppolito Jurkiewicz
Jan 1, 1991·Journal of Neural Transmission. General Section·N H JurkiewiczA G Garcia
Nov 19, 2015·The American Journal of Drug and Alcohol Abuse·Guilherme Henrique Souza BomfimNeide Hyppolito Jurkiewicz
Jul 12, 1995·Annals of the New York Academy of Sciences·A Caricati-NetoA Jurkiewicz
Aug 24, 2011·Journal of Veterinary Pharmacology and Therapeutics·F J Teixeira-NetoL Grovum
Jun 1, 1981·Journal of Autonomic Pharmacology·A Gibson, C V Wedmore
Dec 1, 1981·British Journal of Pharmacology·P DemichelJ Roquebert
Oct 22, 2004·European Journal of Pharmacology·Afonso Caricati-NetoAron Jurkiewicz
Jan 29, 2005·British Journal of Pharmacology·Isaltino M ConceiçãoLúcia Garcez-do-Carmo
Apr 1, 1997·Medical and Veterinary Entomology·P M FinneganM J Gormally
Oct 1, 1992·British Journal of Pharmacology·N H JurkiewiczA Jurkiewicz
Aug 27, 2013·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Diego C MusialNeide H Jurkiewicz
Jun 3, 2014·European Journal of Pharmacology·Bruno Palmieri de SouzaNeide Hyppolito Jurkiewicz
Oct 2, 2014·Andrology·E D da Silva JúniorN H Jurkiewicz
Nov 1, 1988·The Journal of Pharmacy and Pharmacology·A R Brito, A Jurkiewicz
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Aron JurkiewiczNeide H Jurkiewicz
Jul 31, 2018·Clinical and Experimental Pharmacology & Physiology·Diego Castro MusialNeide Hyppolito Jurkiewicz
Oct 1, 1989·Medicinal Research Reviews·J C McGrathV G Wilson
Mar 1, 1980·The Journal of Pharmacy and Pharmacology·M H CreuzetJ Roquebert
Jul 23, 2013·European Journal of Pharmacology·Edilson Dantas da Silva JúniorNeide Hyppolito Jurkiewicz
Nov 8, 2019·European Journal of Pharmacology·Mayara Samala BezerraEdilson Dantas da Silva Junior
Feb 4, 2014·European Journal of Pharmacology·Edilson Dantas da Silva JúniorNeide H Jurkiewicz
Jun 6, 2003·European Journal of Pharmacology·Rosana de A RibeiroAron Jurkiewicz
Oct 9, 2008·European Journal of Pharmacology·Adriana Gonzalez ValeraNeide Hyppolito Jurkiewicz

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