PMID: 11317692Apr 25, 2001Paper

Dual effect of chronic nicotine administration: augmentation of jejunitis and amelioration of colitis induced by iodoacetamide in rats

International Journal of Colorectal Disease
R EliakimD Rachmilewitz

Abstract

Smoking has a dichotomous effect on inflammatory bowel disease, ameliorating disease activity in ulcerative colitis but having a deleterious effect on Crohn's disease. This effect is thought to be due to nicotine. We investigated the effect of chronic nicotine administration on the small and large bowel in iodoacetamide-induced jejunitis and colitis. Jejunitis was induced in Sprague-Dawley rats by intrajejunal administration of 0.1 ml 2% iodoacetamide and colitis by intrarectal administration of 0.1 ml 3% iodoacetamide. Nicotine was dissolved in drinking water (12.5 or 250 micrograms/ml), rats drinking ad libitum. Nicotine administration started 10 days prior to damage induction and throughout the experiment and had no effect on weight gain or daily food intake of rats. Rats were killed 5 days after iodoacetamide-induced colitis and 7 days after induction of jejunitis. The jejunum and colon were resected, rinsed, weighed, damage assessed macroscopically and microscopically and tissue processed for myeloperoxidase and nitric oxide synthase (NOS) activities and prostaglandin E2 (PGE2) generation. Effects of nicotine on gut microcirculation were also assessed. Nicotine by itself caused no damage to the colon. Nicotine had a dichot...Continue Reading

Citations

Dec 11, 2008·Inflammatory Bowel Diseases·Philippe SeksikJacques Cosnes
May 30, 2002·Nature Reviews. Immunology·Mohan Sopori
Jun 20, 2002·European Journal of Gastroenterology & Hepatology·Rami EliakimMark W Babyatsky
Nov 2, 2012·The Journal of Pharmacology and Experimental Therapeutics·Shakir D AlSharariM Imad Damaj
Jul 21, 2009·PloS One·Marian C AldhousJack Satsangi
Jan 21, 2012·Journal of Crohn's & Colitis·Stephanie VerschuereClaude A Cuvelier
Jan 17, 2016·Autoimmunity Reviews·Carlo PerriconeYehuda Shoenfeld
Feb 18, 2016·International Journal of Inflammation·Steven R Vigna
Oct 18, 2012·Alimentary Pharmacology & Therapeutics·P C Lunney, R W L Leong
May 26, 2004·Best Practice & Research. Clinical Gastroenterology·Jacques Cosnes
Jul 19, 2005·Journal of Neuroimmunology·Lorise C GahringScott W Rogers
Jul 6, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Francesca TavanoPierluigi di Sebastiano
Jan 1, 2011·Diabetes & Metabolic Syndrome·Velio BocciValter Travagli
Jun 15, 2007·Journal of Clinical Pharmacology·Bruce E Sands, Gilaad G Kaplan
Apr 17, 2009·The Cochrane Database of Systematic Reviews·Ramesh Srinivasan, Anthony K Akobeng
Feb 5, 2004·World Journal of Gastroenterology : WJG·Shao-Heng He
Oct 13, 2006·Current Opinion in Gastroenterology·Scott M Montgomery, Anders Ekbom
Jul 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Valentin GalitovskiySergei A Grando
Jul 27, 2017·Oxidative Medicine and Cellular Longevity·Tian TianJinhua Zhang
Jul 22, 2018·Gastroenterology Research and Practice·Siyan Stewart Cao
Dec 3, 2017·Best Practice & Research. Clinical Gastroenterology·Gabriele Capurso, Edith Lahner

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