Dual effect of statin medication on the periodontium

Journal of Clinical Periodontology
Tuomas SaxlinPekka Ylöstalo

Abstract

The aim of this study was to investigate the association between statin medication and periodontal infection in an adult population. The study was based on a subpopulation of the Health 2000 Survey, which included dentate non-diabetic, non-rheumatic subjects who did not smoke, aged 40-69 years (n=2032). The main outcome variable was the number of teeth with periodontal pockets of 4 mm or more. Statin medication was categorized in two ways: firstly, subjects with statin medication of some sort (n=134) versus those with none, and secondly, subjects taking either simvastatin (n=58), atorvastatin (n=38), some other statin (n=38) or no statin medication. Relative risks (RR) were estimated using negative binomial and Poisson regression models. We found a weak negative association between statin medication and periodontal infection among subjects with dental plaque or gingival bleeding. Among subjects with no gingival bleeding, statin medication was found to be associated with an increased likelihood of having deepened periodontal pockets. Statin medication appears to have an effect on the periodontium that is dependent on the inflammatory condition of the periodontium. More evidence is needed to achieve a comprehensive understanding ...Continue Reading

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Citations

Apr 4, 2012·Journal of Periodontology·Aditi SangwanSatish C Narula
Dec 7, 2013·Journal of Periodontology·Peter MeiselThomas Kocher
Jan 11, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yijia ZhangRichard A Reinhardt
Sep 10, 2010·Journal of Clinical Periodontology·Martha Eugenia FajardoEmanuel Jaime Espinosa-Chávez
Jul 21, 2011·Journal of Clinical Periodontology·Satu KorhonenPekka Ylöstalo
Apr 21, 2010·Periodontology 2000·P Mark BartoldDavid R Haynes
Dec 9, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Erwan de MonèsJean-Christophe Fricain
Dec 3, 2014·British Journal of Clinical Pharmacology·Ilanna Mara Gomes EstanislauMaria Mônica Studart Mendes Moreira
Aug 23, 2016·Texas Heart Institute Journal·Hanna FröhlichLutz Frankenstein
Jan 5, 2011·Brazilian Dental Journal·Paula GoesVilma Lima
Mar 15, 2011·Journal of Periodontal Research·M CáceresP C Smith
Feb 6, 2018·Clinical Oral Investigations·Francisco Wilker Mustafa Gomes MunizCassiano Kuchenbecker Rösing
Mar 18, 2016·Clinical and Experimental Dental Research·Xianqi LiHideaki Kagami
Feb 27, 2019·Acta Odontologica Scandinavica·Rajeswari SankaranarayananAnna Liisa Suominen
Feb 6, 2020·Journal of Clinical Periodontology·Mariano SanzGernot Wimmer
Jan 23, 2021·International Journal of Environmental Research and Public Health·Ewa Pająk-ŁysekJoanna Zarzecka
Oct 30, 2021·Clinical and Experimental Dental Research·Behzad Bahrami-Hessari, Leif Jansson

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