Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry

Oncotarget
Xiulan ZhaoNa Che

Abstract

Vasculogenic mimicry (VM) is a functional microcirculation formed by tumor cells. Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, promote VM formation. Another specific MMP, collagenase-3 (MMP-13), has broad substrate specificity and potentially affects tumor metastasis and invasion. Here we found that MMP-13 was associated with metastasis and poor survival in 79 patients with melanoma. MMP-13 expression was inversely correlated with VM. These results were confirmed in human and mouse melanoma cell lines. We found that MMP-13 cleaves laminin-5 (Ln-5) into small fragments to accelerate tumor metastasis. Degradation of Ln-5 and VE-cadherin by MMP-13 inhibited VM formation. In conclusion, MMP-13 has a dual effect in melanoma, as it promotes invasion and metastasis but disrupts VM formation.

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Citations

May 30, 2020·Journal of Cellular and Molecular Medicine·Danfang ZhangXu Zheng
Feb 26, 2019·Frontiers in Pharmacology·Giuseppe ErcolanoAngela Ianaro
Dec 1, 2020·Journal of Cellular Physiology·Shih-Wei WangShiou-Sheng Chen

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Methods Mentioned

BETA
transfection
nuclear translocation
nuclear
surgical resection

Software Mentioned

SPSS

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