Abstract
Skin inflammation induced by ultraviolet B (UVB) radiation is characterized by migration and chemotaxis of inflammatory cells, epidermic thickening and erythema. Apoptosis and autophagy of epidermal and dermal cells are involved in its development through the adjustment of balance between cell survival and death. In this study, the role of balance between cell survival and apoptosis in dermis and epidermis in UVB-induced skin inflammation and the effect of autophagy on the balance were elucidated, and the protective mechanism of silibinin was investigated through the examination of the influence of autophagy activation or inhibition on erythema, migration, and chemotaxis of inflammatory cells as well as apoptosis adjustments. In UVB-irradiated controls, dermal apoptosis was retarded and the survival of inflammatory cells was promoted through the up-regulation of dermal autophagic level; epidermal apoptosis was increased through the down-regulation of epidermal autophagic level, causing migration and chemotaxis of neutrophils and mast cells as well as skin erythema. In silibinin-treated group (50 mg/kg/day for 4 days), dermal apoptosis was increased through inhibiting dermal autophagy; improper adjustment of epidermal apoptosis ...Continue Reading
References
Jan 1, 1992·Pharmacology & Therapeutics·J DiGiovanni
Nov 28, 1980·Science·F A Kuehl, R W Egan
Jan 25, 1996·Nature·G J FisherJ J Voorhees
Mar 21, 1998·Lung·Y IshiiM Sagai
Nov 24, 1999·Molecular Carcinogenesis·J ZhaoR Agarwal
Sep 17, 2002·Methods : a Companion to Methods in Enzymology·Daniel B YaroshDavid A Brown
Dec 4, 2003·FEBS Letters·Vishwas D JoshiAlan S Cross
Mar 9, 2004·Apoptosis : an International Journal on Programmed Cell Death·C J van der WoudeH Moshage
Jun 30, 2005·Journal of Cell Science·Rosa-Ana González-PoloGuido Kroemer
Nov 22, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Liying WangRobert R Mercer
Jun 13, 2006·Cell and Tissue Research·Gianluca TettamantiEnzo Ottaviani
Jun 27, 2006·Nature Cell Biology·Chengyu LiangJae U Jung
Jan 4, 2007·The Journal of Pathology·A TermanU T Brunk
Jan 6, 2007·Autophagy·Zhenyu Yue
Apr 6, 2007·Cancer Research·Mallikarjuna GuRajesh Agarwal
Aug 25, 2007·Nature Reviews. Molecular Cell Biology·M Chiara MaiuriGuido Kroemer
Nov 28, 2007·Archives of Pharmacal Research·Kyungwon MinBong-Hee Kim
May 13, 2008·Archives of Biochemistry and Biophysics·Yan ChengTakashi Ikejima
Jan 1, 1995·Mediators of Inflammation·C Haanen, I Vermes
Nov 11, 2008·Biochemical and Biophysical Research Communications·Yahong ZhangTakashi Ikejima
Nov 26, 2008·Biochemical and Biophysical Research Communications·Yahong ZhangTakashi Ikejima
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michal Caspi TalAkiko Iwasaki
Feb 10, 2009·Autophagy·Yan ChengTakashi Ikejima
Citations
Mar 22, 2014·PloS One·Ratana LimMartha Lappas
Dec 29, 2012·International Journal of Molecular Sciences·Sara SalucciElisabetta Falcieri
Apr 24, 2014·BioMed Research International·Madhulika SinghYogeshwer Shukla
Apr 24, 2013·Journal of Photochemistry and Photobiology. B, Biology·Weiwei LiuTakashi Ikejima
Jul 9, 2013·The FEBS Journal·Weiwei LiuTakashi Ikejima
Feb 12, 2013·Biochemical and Biophysical Research Communications·Weiwei LiuTakashi Ikejima
Jun 27, 2018·Antioxidants & Redox Signaling·Francesca GiampieriMaurizio Battino
Feb 8, 2014·International Journal of Molecular Medicine·Hwa Jun ChaSeunghee Bae
Jun 23, 2015·Current Pharmacology Reports·Rahul KumarRajesh Agarwal
Jul 11, 2018·Frontiers in Immunology·Payel SilJennifer Martinez
Feb 10, 2021·Journal of Photochemistry and Photobiology. B, Biology·Weiwei LiuTakashi Ikejima