Dual effects of sodium aescinate on vascular tension in rat thoracic aorta

Microvascular Research
Xia LiShen-Jiang Hu

Abstract

Sodium aescinate (SA) is used as a vasoactive drug in clinical treatment. This study was designed to investigate the effects of SA on rat isolated thoracic aorta and the possible mechanisms. Isometric tension was recorded in response to drugs in organ bath. The effects of SA obeyed an all-or-nothing response. SA in relatively low dose (> or = 50 microg/ml) had an endothelium-independent contractile effect in rat aorta (P<0.01), which depended on extracellular Ca(2+) influx via L-type Ca(2+) channel (P<0.05). SA in relatively high dose (> or = 100 microg/ml) also induced vasoconstriction in Ca(2+)-free medium (P<0.01), which was independent of the activity of inositol-1,4,5-trisphosphate receptor (IP(3)R), ryanodine receptor (RYR), and protein kinase C (PKC). SA in relatively high dose (> or = 100 microg/ml) dilated both endothelium-intact and endothelium-denuded aortic rings precontracted by phenylephrine (PE) or KCl (each P<0.01). SA inhibited extracellular Ca(2+) influx induced by PE or KCl (each P<0.01) and had no activation effect on K(+) channels on vascular smooth muscle. The relaxant effect of SA partly depended on the activity of NO synthase but not on the activity of cyclooxygenase. Taken together, this study indicated...Continue Reading

References

Aug 1, 1977·Prostaglandins·F BertiD Longiave
Aug 1, 1987·Journal of Pharmacological Methods·H Karaki
Jul 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·M A NogueraP D'Ocon
Sep 1, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C R Sirtori
Apr 18, 2003·Current Drug Targets·Sophocles Chrissobolis, Christopher G Sobey
Apr 5, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·William F Jackson
Nov 19, 2005·Journal of Pharmacological Sciences·Hikaru Tanaka, Koki Shigenobu
Feb 14, 2006·Current Pharmaceutical Design·David J Triggle
Mar 11, 2006·Vascular Pharmacology·Hok Sum LeungYu Huang
May 9, 2007·Current Treatment Options in Cardiovascular Medicine·Suman W Rathbun, Angelia C Kirkpatrick

❮ Previous
Next ❯

Citations

Apr 22, 2014·International Journal of Molecular Sciences·Xiaojiang QinQingshan Li
Jan 6, 2016·Life Sciences·Maryam RameshradRohollah Fadaei Fouladi
Apr 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yean Chun LohMun Fei Yam
Feb 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinfeng LiangThomas Efferth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.