Dual-energy CT discrimination of iodine and calcium: experimental results and implications for lower extremity CT angiography

Academic Radiology
David N TranDominik Fleischmann

Abstract

The purpose of this work was to measure the accuracy of dual-energy computed tomography for identifying iodine and calcium and to determine the effects of calcium suppression in phantoms and lower-extremity computed tomographic (CT) angiographic data sets. Using a three-material basis decomposition method for 80- and 140-kVp data, the accuracy of correctly identified contrast medium and calcium voxels and the mean attenuation before and after calcium suppression were computed. Experiments were first performed on a phantom of homogenous contrast medium and hydroxyapatite samples with mean attenuation of 57.2, 126, and 274 Hounsfield units (HU) and 50.0, 122, and 265 HU, respectively. Experiments were repeated in corresponding attenuation groups of voxels from manually segmented bones and contrast medium-enhanced arteries in a lower-extremity CT angiographic data set with mean attenuation of 293 and 434 HU, respectively. Calcium suppression in atherosclerotic plaques of a cadaveric specimen was also studied, using micro-computed tomography as a reference, and in a lower-extremity CT angiographic data set with substantial below-knee calcified plaques. Higher concentrations showed increased accuracy of iodine and hydroxyapatite ide...Continue Reading

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Citations

Aug 24, 2011·Pediatric Radiology·R Paul Guillerman
Jan 21, 2011·European Radiology·Dominik Fleischmann, F Edward Boas
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Apr 30, 2021·Physics in Medicine and Biology·Tonghe WangXiaofeng Yang

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