Dual-function nanosystem for synergetic cancer chemo-/radiotherapy through ROS-mediated signaling pathways

Biomaterials
Lizhen HeTianfeng Chen

Abstract

Radioresistance and limitation of irradiative dosage usually lead to failure in depletion of hypoxic tumors. Herein we developed multifunctional mesoporous silica nanoparticles (MSNs) as a carrier of a novel anticancer selenoamino acid (selenocystine, SeC), to achieve synergistic chemo-/radiotherapy. This multifunctional nanosystem effectively sensitizes cancer cells to X-ray radiotherapy. Conjugation of TAT cell penetrating peptide and transferrin to the surface of MSNs significantly enhances its internalization in cancer cells through receptor-mediated endocytosis. SeC@MSNs-Tf/TAT significantly enhanced X-ray-induced growth inhibition in cervical cancer cells by induction of apoptosis, mainly through death receptor-mediated extrinsic apoptotic pathway. Upon radiation, SeC@MSNs-Tf/TAT promoted intracellular ROS overproduction, which induced apoptotic cell death by affecting p53, AKT and MAPKs pathways. Furthermore, SeC@MSNs-Tf/TAT also significantly inhibited HeLa tumor growth in nude mice model through suppression of cell proliferation and induction of apoptosis. In vivo toxicity of the SeC@MSNs-Tf/TAT nanoparticles was investigated using the mouse model. The results of histological analysis revealed that, the nanoparticles d...Continue Reading

References

May 15, 2002·Trends in Pharmacological Sciences·Hongyan LiZhong Ming Qian
Feb 18, 2004·Current Cancer Drug Targets·E I AzzamJ B Little
May 26, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Helene PelicanoPeng Huang
Mar 2, 2005·Nature Reviews. Cancer·Mauro Ferrari
May 4, 2005·Nucleic Acids Research·Reto Brem, Janet Hall
Apr 19, 2006·Cancer Research·Golnar AfsharDaphne A Haas-Kogan
Nov 22, 2007·Bioorganic & Medicinal Chemistry·Takashi NakaeHitoshi Hori
May 31, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tianfeng Chen, Yum-Shing Wong
Jul 26, 2008·Nature Nanotechnology·Mauro Ferrari
Feb 12, 2009·ACS Nano·Omid C Farokhzad, Robert Langer
Jun 16, 2009·Nature Materials·Andre E NelMike Thompson
Jan 16, 2010·Mutation Research·K KobayashiC Le Sech
Jan 27, 2010·Journal of the American Chemical Society·Paul D Thornton, Andreas Heise
Mar 17, 2010·Journal of the American Chemical Society·Yu-Shen Lin, Christy L Haynes
Jul 17, 2010·International Journal of Toxicology·Jeffrey W Card, Bernadene A Magnuson
Sep 30, 2010·Small·Caterina MinelliMolly M Stevens
Mar 25, 2011·Advanced Materials·José A BarretoLeone Spiccia
Mar 29, 2011·Cancer Letters·Hiroshi HoshikawaNozomu Mori
May 18, 2011·Journal of the American Chemical Society·Faheem MuhammadGuangshan Zhu
Oct 11, 2011·Journal of the American Chemical Society·Neetu SinghSangeeta N Bhatia
Dec 6, 2011·Chemical Research in Toxicology·Masanori HorieHitoshi Iwahashi
Mar 17, 2012·Journal of the American Chemical Society·Limin PanJianlin Shi
Apr 24, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Y C ZengQ Y Guo
Jul 19, 2012·Nature Communications·Eisaku KondoMasayuki Matsushita
Feb 21, 2013·Chemical Communications : Chem Comm·Zane B StarkewolfTing Guo
Dec 20, 2013·Science Translational Medicine·Edward Kai-Hua Chow, Dean Ho

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Citations

Jan 20, 2016·Nanomedicine·Jessica Maria RosenholmCecilia Sahlgren
Jan 17, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Virginia J YaoRenata Pasqualini
Mar 19, 2016·Cancer Letters·Chloé RancouleCyrus Chargari
Aug 4, 2015·Molecular Pharmaceutics·Qianyu ZhangQin He
Jun 22, 2016·Chemistry, an Asian Journal·Wei HuangTianfeng Chen
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O ElzoghbyMay S Freag
Feb 6, 2018·Chemistry, an Asian Journal·Xueyang FangTianfeng Chen
Jan 24, 2018·Technology in Cancer Research & Treatment·Li LiaoGu-Qing Zeng
Jun 24, 2017·Advanced Materials·Guosheng SongZhuang Liu
Jun 26, 2018·Advanced Healthcare Materials·Bowen YangJianlin Shi
Aug 30, 2018·Advanced Materials·Jiani XieYuliang Zhao
Mar 7, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Zushuang XiongTianfeng Chen
May 8, 2019·Journal of Cellular and Molecular Medicine·Xu Jiang, Jun Wang
Nov 30, 2019·Chemical Communications : Chem Comm·Zhen ChenTianfeng Chen
Apr 17, 2019·Nanomaterials·Hai-Jun Liu, Peisheng Xu
Feb 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xueyang FangTianfeng Chen
Jun 20, 2017·International Journal of Oncology·Dan TianFeiyue Fan
Jul 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Leung ChanTianfeng Chen
Sep 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuanyuan YouTianfeng Chen
Jan 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhenhuan SongTianfeng Chen
Apr 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingxian LiuChangren Zhou
Nov 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lizhen HeTianfeng Chen

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