Dual-functional bio-derived nanoparticulates for apoptotic antitumor therapy

Biomaterials
Yang DingJianping Zhou

Abstract

The application of bio-derived nanoparticulates has gained a remarkable degree of interest as a promising sustained-release, site-targeted and completely biodegradable delivery system for chemotherapeutics. We hereby introduce a dual-functionalized biomimetic nanovector, cell-penetrating peptide (CPP)-anchored recombinant high density lipoproteins (cp-rHDL), which affords high payload and improved targeting of gambogic acid (GA), a therapeutic agent for apoptotic antitumor therapy. GA-loaded cp-rHDL nanoparticles (cp-rHDL/GA) consisted of hydrophobic core modulating GA, apolipoprotein A-I (apo A-I) for attractive integrating and tumor-homing, and lipophilic anchored R6H4 (RRRRRRHHHH, a pH-responsive CPP) offering a pH-controlled penetrating potential. Upon stepwise incubation with apo A-I and R6H4, cp-rHDL/GA presented several merits, including desirable physicochemical properties, superior biostability, and favorable buffering capacity resulting in proton sponge effect. Synergistic intracellular mechanism for scavenger receptor class B type I (SR-BI)-mediated direct transmembrane delivery, and pH-responsive R6H4 associated endocytotic pathway with rapid endo-lysosomal escape was also observed. This tailored cp-rHDL/GA displaye...Continue Reading

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Citations

Mar 12, 2016·Investigative and Clinical Urology·Vinoth-Kumar Lakshmanan
Oct 13, 2016·Frontiers in Pharmacology·Maneesha A Rajora, Gang Zheng
Jan 26, 2020·International Journal of Molecular Sciences·Soumaya Ben-AichaGemma Vilahur
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Jan 15, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Huaqing ZhangYang Ding
Jul 20, 2021·Journal of Nanobiotechnology·Pengkai WuKaikai Wang
Aug 23, 2017·ACS Applied Materials & Interfaces·Yang DingJianping Zhou

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