Dual functional regulators coordinate DNA replication and gene expression in proliferating cells

Frontiers in Bioscience : a Journal and Virtual Library
Bik K Tye, Victoria K Chang

Abstract

Gene products for cell growth must meet the pace of DNA replication and vice versa during the cell division cycle, therefore coordination of DNA replication and gene expression is vital to proliferating cells. During development in multicellular organisms when rapid cell divisions must be accompanied by the expression of particular gene sets in differentiating tissues, this coordination is even more crucial. Undoubtedly, multiple strategies are used to ensure the coordination of gene expression and DNA replication. In this review, we focus on the strategy that uses dual functional factors to serve both the functions of replication initiator and transcription regulator. Classical examples are the dual functional replication initiator/transcription regulators, DnaA of E. coli and T antigen of SV40, which bind replication origins and regulate their own synthesis. Emerging examples in eukaryotes are the growth responsive transcription factor E2f, the MADS domain combinatorial transcription factor Mcm1, and a subunit of the MCM2-7 helicase, Mcm7.

Citations

Nov 16, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takayo OtaJeremy R Chien
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Soma BanerjeeKyungjae Myung
Dec 21, 2005·Genome Research·Qiang SunJoseph M Miano
Dec 3, 2010·Trends in Cell Biology·Graham ScholefieldHeath Murray
May 24, 2018·Development, Growth & Differentiation·Makoto KashimaNorito Shibata
Aug 11, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eric LauWei Jiang

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