Dual gated PET/CT imaging of small targets of the heart: method description and testing with a dynamic heart phantom.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Tommi KokkiJuhani Knuuti

Abstract

In PET imaging respiratory and cardiac contraction motions interfere the imaging of heart. The aim was to develop and evaluate dual gating method for improving the detection of small targets of the heart. The method utilizes two independent triggers which are sent periodically into list mode data based on respiratory and ECG cycles. An algorithm for generating dual gated segments from list mode data was developed. The test measurements showed that rotational and axial movements of point source can be separated spatially to different segments with well-defined borders. The effect of dual gating on detection of small moving targets was tested with a moving heart phantom. Dual gated images showed 51% elimination (3.6 mm out of 7.0 mm) of contraction motion of hot spot (diameter 3 mm) and 70% elimination (14 mm out of 20 mm) of respiratory motion. Averaged activity value of hot spot increases by 89% when comparing to non-gated images. Patient study of suspected cardiac sarcoidosis shows sharper spatial myocardial uptake profile and improved detection of small myocardial structures such as papillary muscles. The dual gating method improves detection of small moving targets in a phantom and it is feasible in clinical situations.

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Citations

Oct 1, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Mika TeräsJuhani Knuuti
Apr 27, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ilse A VermeltfoortPaul Knaapen
Jan 1, 2013·PET Clinics·V BettinardiM C Gilardi
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Aug 15, 2014·International Journal of Biomedical Imaging·Mojtaba Jafari TadiAri Paasio
Jun 30, 2015·PloS One·Miikka TarkiaJuhani Knuuti
Sep 8, 2017·Physics in Medicine and Biology·Mojtaba Jafari TadiMika Teräs
Jan 27, 2019·Annals of Nuclear Medicine·Matti J KortelainenMikko A Hakulinen
Jan 16, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A TurcoP Claus
Mar 11, 2011·Physics in Medicine and Biology·G DelsoM Schwaiger
Feb 24, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Tommi KokkiJuhani Knuuti
Nov 11, 2020·Scientific Reports·R KlénJ Knuuti
Sep 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jussi SchultzJarmo Teuho

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