PMID: 15237709Jul 9, 2004Paper

Dual growth hormone (GH) response to repeated GH releasing hormone stimulus in children and adults

Journal of Pediatric Endocrinology & Metabolism : JPEM
A VelaM A Busturia

Abstract

Several authors have demonstrated that plasma growth hormone (GH) levels as response to acute GH releasing hormone (GHRH) stimulation in adults are decreased by a previous GHRH injection whereas they are maintained in children. Probably the most accepted hypothesis for this finding is the increase in the somatostatinergic tone. The aim of the present study was to evaluate the dual GH response to repeated GHRH stimuli to clarify the possible influence of somatostatinergic activity in the type of response. Eighteen healthy prepubertal children, mean age 9.2 years (range: 6.0-12.9 years) and 19 healthy adult volunteers, mean age 25.5 years (range: 17-35 years) were studied with the GHRH test. An additional group of 10 normal adults with similar characteristics (mean age 31 years, range 25-35 years) were also recruited as a control group for somatostatinergic assessment. The GH response to the first GHRH bolus was similar in both children and adults. However, while children showed a preserved response to the second stimulus, it was diminished in adults. As expected, thyroid stimulating hormone (TSH) was within the normal range in all subjects. When the evolution of TSH was compared between the group of non-responders and the contro...Continue Reading

References

Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·G BrabantA von zur Mühlen
Sep 1, 1990·Acta Endocrinologica·Z LaronI Gil-Ad
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J Alba-RothK von Werder
Nov 1, 1988·Journal of Endocrinological Investigation·A SartorioG Faglia
Aug 12, 1983·Biochemical and Biophysical Research Communications·P BöhlenR Guillemin
Jan 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T ShibasakiN Ling
May 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M L VanceS Bloom
Feb 24, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·E GhigoF Camanni
Mar 15, 2003·Hormone Research·Fabio BroglioEzio Ghigo

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Citations

Apr 6, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R CoyaP Martul

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