Dual histamine receptor mechanism in guinea-pig lung

Pharmacology
N Chand, L DeRoth

Abstract

Isolated guinea-pig lung parenchymal strips (GPLS) relaxed in response to the selective histamine H2-receptor agonists, dimaprit and 4-methylhistamine (4-MeH), and to low doses of histamine (10(-9) to 10(-7) mol/l) and contracted in response to several spasmogens. The order of the relative activity of the spasmogens was 2-methylhistamine (2-MeH) greater than histamine greater than carbachol greater than 2-pyridylethylamine (2-PE). Dimaprit and 4-MeH also relaxed GPLS which were contracted by 2-MeH, 2-PE or carbachol. Metiamide (a selective H2-antagonist: 5 x 10(-5) mol/l inhibited or reversed relaxations to histamine, dimaprit and 4-MeH, and significantly enhanced contractile responses to histamine without altering responses to carbachol. Mepyramine (a selective H1-receptor antagonist: 10(-8) to 10(-6) mol/l antagonized histamine-induced contractions. This investigation shows: (1) histamine is more active than carbachol in GPLS and (2) the occurrence of histamine H1-receptors mediating contraction and H2-receptors mediating relaxation in guinea-pig lung.

References

Oct 1, 1984·Agents and Actions·J C WilliamsP Townshend-Piala
Feb 17, 1984·European Journal of Pharmacology·K VincencJ Shaw
Apr 25, 1989·European Journal of Pharmacology·M Ichinose, P J Barnes
Jan 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Arul VeerappanRandi B Silver
May 1, 1989·British Journal of Pharmacology·M IchinoseP J Barnes

Related Concepts

Receptors, Histamine H1
Histamine H2 Receptors
Carboptic
Lung
Metiamide Monohydrochloride
Smooth Muscle
Histamine Receptor
Antihistamines, Classical
Methylhistamines
Histamine H2 Antagonists

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