Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors

The Journal of Clinical Investigation
D SalveminiJ L Masferrer

Abstract

We have recently put forward the hypothesis that the dual inhibition of proinflammatory nitric oxide (NO) and prostaglandins (PG) may contribute to the antiinflammatory properties of nitric oxide synthase (NOS) inhibitors. This hypothesis was tested in the present study. A rapid inflammatory response characterized by edema, high levels of nitrites (NO2-, a breakdown product of NO), PG, and cellular infiltration into a fluid exudate was induced by the administration of carrageenan into the subcutaneous rat air pouch. The time course of the induction of inducible nitric oxide synthase (iNOS) protein in the pouch tissue was found to coincide with the production of NO2-. Dexamethasone inhibited both iNOS protein expression and NO2- synthesis in the fluid exudate (IC50 = 0.16 mg/kg). Oral administration of N-iminoethyl-L-lysine (L-NIL) or NG-nitro-L-arginine methyl ester (NO2Arg) not only blocked nitrite accumulation in the pouch fluid in a dose-dependent fashion but also attenuated the elevated release of PG. Finally, carrageenan administration produced a time-dependent increase in cellular infiltration into the pouch exudate that was inhibited by dexamethasone and NOS inhibitors. At early times, i.e., 6 h, the cellular infiltrate ...Continue Reading

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V RettoriS M McCann
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L MasferrerP Needleman
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
May 8, 1991·Biochimica Et Biophysica Acta·D L DeWitt
Oct 1, 1990·The Journal of Clinical Investigation·J L MasferrerP Needleman
Dec 1, 1983·The Journal of Pathology·A D SedgwickD A Willoughby
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Oct 1, 1993·Analytical Biochemistry·T P MiskoM G Currie
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J R VaneD A Willoughby
May 1, 1994·The Journal of Clinical Investigation·D SalveminiP Needleman
Nov 11, 1994·Journal of Medicinal Chemistry·W M MooreM G Currie
Jan 24, 1995·European Journal of Pharmacology·J R ConnorM G Currie
Mar 1, 1995·British Journal of Pharmacology·D SalveminiP Needleman
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiP Needleman
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L MasferrerK Seibert
Jul 15, 1993·Biochemical and Biophysical Research Communications·T InoueT Ogihara

❮ Previous
Next ❯

Citations

Feb 19, 2000·Biochemical and Biophysical Research Communications·S HondaK Eguchi
Dec 16, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Mirna M BezerraFrancisco A C Rocha
Jun 23, 2005·Pflügers Archiv : European journal of physiology·Evelin C CarnioSheldon Magder
May 15, 1996·European Journal of Pharmacology·D SalveminiP T Manning
Jan 28, 2004·European Journal of Pharmacology·Stefania MarzoccoGiuseppina Autore
May 30, 1998·Biochemical Pharmacology·L SautebinM Di Rosa
Mar 26, 2003·European Journal of Pharmacology·Javier RojasMa Luisa Ferrándiz
Jul 4, 1998·European Journal of Pharmacology·L Franco, D Doria
Feb 8, 2006·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·N Ni Choileain, H P Redmond
Feb 1, 1997·British Journal of Pharmacology·B ZingarelliC Szabó
Nov 23, 2000·British Journal of Pharmacology·S CuzzocreaA P Caputi
Feb 22, 2001·British Journal of Pharmacology·D SalveminiS Cuzzocrea
Jan 30, 2002·British Journal of Pharmacology·Salvatore CuzzocreaChristoph Thiemermann
Jun 11, 2002·British Journal of Pharmacology·José C da S RochaFrancisco A C da Rocha
Jun 1, 1997·Alimentary Pharmacology & Therapeutics·S FiorucciA Morelli
Jun 18, 1999·Journal of Veterinary Pharmacology and Therapeutics·R P HunterA A Dees
Jun 1, 1996·British Journal of Pharmacology·D SalveminiM G Currie
Jun 22, 2002·Annals of the New York Academy of Sciences·Ding-I YangChung Y Hsu
Jan 1, 1996·Mediators of Inflammation·Y S Bakhle, R M Botting
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S A KharitonovK F Chung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
D SalveminiP Needleman
Prostaglandins, Leukotrienes, and Essential Fatty Acids
M Di RosaL Sautebin
© 2021 Meta ULC. All rights reserved