Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease

Future Medicinal Chemistry
Damijan KnezStanislav Gobec

Abstract

Accumulating evidence indicates a solid relationship between several enzymes and Alzheimer's disease. Cholinesterases and monoamine oxidases are closely associated with the disease symptomatology and progression and have been tackled simultaneously using several multifunctional ligands. This design strategy offers great chances to alter the course of Alzheimer's disease, in addition to alleviation of the symptoms. More than 15 years of research has led to the identification of various dual cholinesterase/monoamine oxidase inhibitors, while some showing positive outcomes in clinical trials, thus giving rise to additional research efforts in the field. The aim of this review is to provide an update on the novel dual inhibitors identified recently and to shed light on their therapeutic potential.

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Citations

May 16, 2017·Future Medicinal Chemistry·Maria Laura Bolognesi
Feb 13, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Jie YangXiaojing Wang
Sep 21, 2019·Mini Reviews in Medicinal Chemistry·Yaghoub PourshojaeiAli Asadipour
Nov 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Isabella BologninoMarco Catto
Jul 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lazhar ZribiFakher Chabchoub
Dec 20, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Martín Estrada-ValenciaMaría Isabel Rodríguez-Franco
Jul 3, 2020·International Journal of Molecular Sciences·Francesca AnnunziataAndrea Pinto
Apr 5, 2020·The Journal of Pharmacy and Pharmacology·Fathima Sahla Kavully Bijo Mathew
Oct 22, 2020·International Journal of Molecular Sciences·Irene Pachón AngonaLhassane Ismaili
Jan 26, 2021·European Journal of Medicinal Chemistry·Francesco MesitiFernanda Borges
Oct 28, 2019·Mini Reviews in Medicinal Chemistry·Miroslav Pohanka
May 29, 2021·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·İsmail Okan AteşLeyla Yurttaş
Jan 1, 2020·ACS Omega·Carina LemkeMichael Gütschow

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