Dual Ionically Cross-linked Double-Network Hydrogels with High Strength, Toughness, Swelling Resistance, and Improved 3D Printing Processability

ACS Applied Materials & Interfaces
Xuefeng LiZi Liang Wu

Abstract

We report a dual ionic cross-linking approach for the preparation of double-network hydrogels with robustness, high strength, and toughness, sodium alginate/poly(acrylamide- co-acrylic acid)/Fe3+ (SA/P(AAm- co-AAc)/Fe3+), in a facile "one-step" dual ionic cross-linking method. We take advantage of the abundant carboxyl groups on alginate molecules and the copolymer chains and their high coordination capacity with multivalent metal ions to obtain hydrogels with high strength and toughness. The optimal SA/P(AAm- co-AAc)/Fe3+ (SA 2 wt % and AAc 5 mol %) hydrogels showed a remarkable mechanical performance with 3.24 MPa tensile strength and 1228% strain, both of which remained stable with 76% water content and were highly swelling resistant in an aqueous environment. The hydrogels possessed high fatigue resistance, self-recovery, pH-triggered healing capability, shape memory, and reversible gel-sol transition facilitated by pH regulation. Moreover, they show three-dimensional (3D) printing processability by properly adjusting the solution viscosity. The approach may provide a convenient way of obtaining hydrogels having high strength and toughness with a number of desirable properties for a broad range of biomedical applications.

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Citations

Feb 20, 2019·Macromolecular Rapid Communications·Zhongying JiFeng Zhou
Apr 3, 2019·Angewandte Chemie·Xiong-Fei ZhangJianfeng Yao
May 16, 2019·Chemistry : a European Journal·Longyu LiChenfeng Ke
Jul 20, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Dan ZhouXuechang Zhou
Jan 4, 2020·Biofabrication·Małgorzata K Włodarczyk-BiegunAranzazu Del Campo
Oct 2, 2020·Advanced Science·Zhen JiangLuke A Connal
Oct 24, 2020·Chemical Communications : Chem Comm·Xiaohu ZhouXuechang Zhou
Jan 26, 2021·Macromolecular Rapid Communications·Shijun LongXuefeng Li
Dec 18, 2020·Frontiers in Chemistry·Kang LuMingzai Wu
Feb 20, 2021·ACS Biomaterials Science & Engineering·Ana A AldanaLouis M Pitet
Feb 23, 2021·Frontiers in Bioengineering and Biotechnology·Na LiZhenyu Jason Zhang
Mar 16, 2021·ACS Applied Materials & Interfaces·Donghao ZhaoWei Yang
Sep 21, 2020·Trends in Biotechnology·Abhishek P DhandJason A Burdick
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Yiwei ZhanChunying Chen
Aug 17, 2021·ACS Biomaterials Science & Engineering·Jarrod CohenJoachim Kohn
Sep 10, 2021·Biomaterials Science·Matteo HirschEsther Amstad
Jan 5, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cong DuQiang Zheng

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